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METHYLPROPANEDIOL.

Valuable CAS 2163-42-0 / SOLVENT

Methylpropanediol is a versatile organic diol that serves as an exceptional solvent, significantly improving the delivery and absorption of active ingredients into the skin. It also functions as a potent humectant, drawing and retaining vital moisture, while simultaneously enhancing overall product stability and extending shelf life.

Summary

solvent humectant preservative booster antimicrobial formula stabilizer viscosity modifier skin-hydrating

Science

Mechanism of Action

Methylpropanediol primarily acts as an excellent solvent, facilitating the uniform distribution and deeper penetration of other key active ingredients, such as salicylic acid, into the skin. As a humectant, it attracts and binds water, effectively hydrating the skin, fortifying the skin barrier, and minimizing transepidermal water loss (TEWL), especially beneficial for mature skin. Furthermore, it exhibits antimicrobial properties that boost the effectiveness of preservatives, acts as a crucial formula stabilizer by integrating components and extending product longevity, and can also modify formulation viscosity for optimal texture and spreadability.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This ingredient is crucial for maintaining overall formula integrity, connecting diverse components, preventing degradation, and extending product shelf life. Its presence improves freeze-thaw stability in emulsions and actively prevents phase separation. The unique branched and asymmetric molecular structure of methylpropanediol inhibits crystallization, ensuring the formulation remains liquid and stable even under colder conditions.

Synergies

  • enhances penetration of active ingredients (e.g., salicylic acid)
  • boosts efficacy of preservatives

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has thoroughly evaluated methylpropanediol, concluding its safety for use in cosmetic applications at current concentrations and practices, noting no reported irritation or sensitization. While general skin irritation precautions are prudent for any ingredient, CIR's assessment indicates a demonstrably low risk profile for methylpropanediol. The FDA also lists methylpropanediol in the Code of Federal Regulations (CFR) Title 21 for various non-cosmetic uses.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Methylpropanediol is a valuable multi-functional ingredient, crucial for enhancing active ingredient delivery, providing substantial hydration, and significantly bolstering formula stability and preservative efficacy, making it well-suited for all skin types due to its low irritancy and comedogenicity.

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