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Moumoujus

METHYLMETHIONINE.

Valuable CAS 4727-40-6 / ASTRINGENT, ORAL CARE, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

METHYLMETHIONINE, also known as Vitamin U, is a multifaceted amino acid derivative offering comprehensive skin support. It provides potent antioxidant and photoprotective benefits, while actively promoting wound healing and cellular regeneration for improved skin health.

Summary

Antioxidant Photoprotective Wound Healing Anti-inflammatory Collagen Booster Cell Regenerator

Science

Mechanism of Action

Methylmethionine functions by enhancing the proliferation and viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs), even post-UVB exposure. It mitigates UVB-induced cellular apoptosis and activates extracellular signal-regulated kinases (ERK). As an antioxidant, it significantly reduces the generation of reactive oxygen species (ROS) caused by UVB. Furthermore, it stimulates collagen synthesis and decreases matrix metalloproteinase-1 (MMP-1) expression in UVB-irradiated hDFs, collectively contributing to its reparative, protective, and anti-inflammatory effects.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While a specific optimal pH range for Methylmethionine's stability in cosmetic formulations is not explicitly stated in the literature, general skincare products are typically formulated between pH 5.0 and 6.0 to be compatible with the skin's natural acidic mantle.

Synergies

  • Permeation enhancers (e.g., oleic acid and ethanol) are recommended to improve the skin's absorption of Methylmethionine due to its high hydrophilicity (log P value of -3.3).

Conflicts

  • The raw ingredient S-Methylmethionine sulfonium (SMMS) may possess an unpleasant odor originating from dimethyl sulfide, leading to the development of odor-free derivatives for cosmetic use.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Methylmethionine (Vitamin U) has been generally reported to exhibit low toxicity. No specific safety assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) for S-Methylmethionine or Vitamin U as a cosmetic ingredient were found.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Methylmethionine is a valuable ingredient in precision skincare, offering robust photoprotective, antioxidant, and regenerative benefits, making it suitable for a broad spectrum of skin types, particularly those needing repair and protection.

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