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Moumoujus

METHYLHEPTENONE ISOMERS.

Optional CAS 409-02-9 / PERFUMING

Methylheptenone Isomers are versatile organic compounds primarily utilized in skincare formulations for their aromatic properties, serving as fragrance enhancers. Notably, a specific isomer, 6-methyl-5-hepten-2-one, also offers a unique benefit by potentially making skin less attractive to mosquitoes, thus functioning as a repellent.

Summary

Perfuming Mosquito Repellent (specific isomer: 6-methyl-5-hepten-2-one)

Science

Mechanism of Action

These isomers predominantly act as fragrance ingredients, enhancing the olfactory profile of a product and/or perfuming the skin. A key aspect of their mechanism for a specific isomer, 6-methyl-5-hepten-2-one, involves its natural presence in human skin volatiles. When formulated, this isomer can influence mosquito odor receptors, making the skin less appealing to various mosquito species and thereby acting as a repellent.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–10%
Optimal

1%

Transparency

Dusting Analysis

Not commonly dusted

Data regarding dusting potential for Methylheptenone Isomers is not available, thus preventing an assessment.

The Formula

Formulation

Solubility
Oil
Optimal pH 3.5 – 10.5
0 7 14

Stability

Pure methyl heptenone maintains good odor stability within a broad pH range of 3.5 to 10.5. Its stability significantly decreases outside this range, showing reduced efficacy at pH 2 and substantial degradation at pH 11.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Methylheptenone Isomers have not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel and are often declared under the INCI name 'PARFUM'. The FDA does not mandate pre-market approval for cosmetic ingredients, and no specific prohibitions or restrictions for these isomers in cosmetics have been identified. The isomer 6-methyl-5-hepten-2-one adheres to IFRA guidelines. A predicted skin absorption value of 80% and a skin sensitization No-Effect Sensitization Induction Level (NESIL) of 4400 μg/cm2 have been reported for 6-methyl-5-hepten-2-one, suggesting a low risk of sensitization in typical cosmetic applications. The Council of Europe permits methyl heptenone at a level of 1 ppm in artificial flavoring substances. GHS classification for the pure substance indicates it is a flammable liquid and can be irritating to skin and eyes, which are factors for raw material handling.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Methylheptenone Isomers are primarily valuable as fragrance components, with a specific isomer offering a niche yet effective mosquito-repellent property, positioning them as an optional choice for aromatic enhancement and targeted protection.

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