Science
Mechanism of Action
This advanced peptide, a derivative of Methyl undecenoyl leucinate, precisely targets and interacts with the Melanocortin 1 Receptor (MC1R). By competitively binding to MC1R, it effectively prevents its activation by the natural ligand, alpha-Melanocyte Stimulating Hormone (alpha-MSH). This critical interruption deactivates a cascade of melanogenic genes, including tyrosinase, TRP1, TRP2 (DCT), MITF, and POMC, thereby blocking the synthesis of melanin. Concurrently, it reduces inflammation induced by UVB radiation, contributing to comprehensive photoprotection.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The raw material is characterized by a neutral pH, suggesting inherent stability within typical cosmetic formulation parameters.
Safety
Safety Profile
Standard dermatological tolerance testing, utilizing an occlusive single patch method on healthy volunteers, indicated no cytotoxic effects, irritation, or sensitization reactions, affirming a low risk profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
METHYL UNDECYLENOYL DIPEPTIDE-16 is a valuable ingredient, offering precise melanin inhibition and anti-inflammatory benefits with broad skin compatibility and a low sensitization risk, though detailed clinical efficacy percentages are not yet publicly established.
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References
Sources