Science
Mechanism of Action
This innovative lipo-amino acid functions as an α-MSH (melanocyte-stimulating hormone) antagonist. It precisely interacts with the Melanocortin 1 Receptor (MC1R), effectively competing with α-MSH to prevent the activation of key genes involved in melanin synthesis, including tyrosinase, TRP1, TRP2 (DCT), MITF, and POMC. This antagonism directly inhibits the formation of new melanin. Furthermore, Methyl Undecenoyl Leucinate efficiently blocks cAMP production, a critical signaling pathway downstream of MC1R, and demonstrates anti-inflammatory properties, particularly against UVB-induced inflammation caused by environmental stimuli.
Research
Clinical Evidence
High confidence3%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Methyl Undecenoyl Leucinate, as part of undecenoyl dipeptide derivatives, exhibits excellent stability. Its small molecular weight and fatty acid affinity contribute to high skin penetration, enhancing its delivery and efficacy.
Safety
Safety Profile
While direct CIR and SCCS safety assessments for Methyl Undecenoyl Leucinate are not available, it has been used in clinical studies within a 3% concentration formula. Undecenoyl dipeptide derivatives, which this ingredient belongs to, are generally regarded as nontoxic, possessing low cytotoxicity and posing no skin irritation risk. A 0.1% concentration is listed in some products, though not FDA-approved as a drug.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Methyl Undecenoyl Leucinate is a valuable active ingredient for precision skincare, demonstrating potent skin brightening and anti-inflammatory effects with a favorable safety profile.
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