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METHYL METHYLBUTYRATE.

Avoid CAS 868-57-5 / PERFUMING

Methyl Methylbutyrate, also identified as Methyl 2-methylbutyrate, is primarily utilized in formulations for its distinct fruity aroma, characterized by notes of apple, pear, and pineapple. Despite its pleasant scent, this compound offers no therapeutic skin benefits and poses significant safety concerns, including potential irritation and sensitization.

Fragrance

Science

Its mechanism on the skin is purely sensorial, functioning as a fragrance agent to impart an appealing scent profile. It does not engage with biological pathways to provide any known beneficial effects or functional changes to the skin's physiology.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

As a fragrance ingredient, Methyl Methylbutyrate is incorporated for sensorial appeal rather than for therapeutic claims, making the concept of 'dusting' for false efficacy irrelevant.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Store tightly closed at room temperature, away from heat and light. While generally heat tolerant, formulations should avoid temperatures exceeding 40°C.


Safety

CIR Status
Not reviewed
Max tested
0.3%
Sensitization risk High

Identified as Methyl 2-methylbutyrate (CAS 868-57-5), this ingredient is generally recognized under FEMA GRAS/FDA for flavor and fragrance applications. However, GHS classifications specifically state it 'Causes skin irritation' (H315) and 'Causes serious eye irritation' (H319). Furthermore, it is listed as a 'Suspected carcinogen' and a 'Suspected skin sensitiser', indicating notable risks.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

Methyl Methylbutyrate is an aroma chemical offering no skin benefits while presenting significant risks of irritation, sensitization, and carcinogenicity, rendering its use in precision skincare formulations highly inadvisable.


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