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Moumoujus

METHYL HYDROXYCINNAMATE.

Valuable CAS 19367-38-5 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, VISCOSITY CONTROLLING

Methyl Hydroxycinnamate, also known as Methyl 4-hydroxycinnamate or Methyl p-coumarate, is a precision skincare ingredient derived from hydroxycinnamic acids. It functions as a powerful antioxidant, exhibits significant anti-inflammatory properties, and demonstrably reduces melanin synthesis.

Summary

Antioxidant Anti-inflammatory Melanin Synthesis Inhibitor Skin Conditioning Agent Emollient Viscosity Controlling Agent Potential UV Absorber/Filter

Science

Mechanism of Action

This compound exerts its antioxidant effects by actively scavenging DPPH radicals, thereby mitigating oxidative stress. Its anti-inflammatory action is evidenced by its capacity to reduce LPS-induced nitric oxide production and suppress the secretion of key pro-inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1. Furthermore, Methyl Hydroxycinnamate inhibits the formation of melanin, contributing to skin brightening. As a derivative of hydroxycinnamic acids, it may also offer a protective role against UV radiation by diminishing inflammation, oxidative damage, and DNA damage, potentially functioning as a UV-absorbing or filtering molecule.

Research

Clinical Evidence

Medium confidence
Effective range 5–772.47%
Optimal

N/A

Key findings

  1. 01 Demonstrated potent antioxidant activity by scavenging DPPH radicals with an IC50 of 772.47 µM in a cell-free assay.
  2. 02 Exhibited anti-inflammatory effects by reducing LPS-induced nitric oxide production in RAW 264.7 cells, with an IC50 of 19.29 µM.
  3. 03 Inhibited melanin formation in B16 mouse melanoma cells, indicating anti-melanogenic properties.
  4. 04 Suppressed the secretion of inflammatory cytokines (IL-6, IL-8, MCP-1, ICAM-1) in PMA-stimulated A549 cells, confirming broad anti-inflammatory action.

Transparency

Dusting Analysis

Not commonly dusted

No available data suggests that Methyl Hydroxycinnamate is commonly 'dusted' or used at ineffective sub-clinical concentrations in formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Stock solutions require careful handling; they should be aliquoted and stored at -80°C for up to 6 months or at -20°C for up to 1 month to prevent inactivation due to repeated freeze-thaw cycles. If precipitation occurs during preparation, heating and/or sonication can aid dissolution.

Synergies

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Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Methyl Hydroxycinnamate has not been directly reviewed for safety by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). The FDA does not typically pre-approve cosmetic ingredients, and this compound is not listed among those restricted or prohibited. Further dedicated safety assessments for topical cosmetic use are needed.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Methyl Hydroxycinnamate is a valuable multi-functional ingredient demonstrating robust antioxidant, anti-inflammatory, and anti-melanogenic properties in in vitro and cell-based studies, making it a promising candidate for precision skincare formulations.

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