Science
Mechanism of Action
Methyl Glycyrrhizate functions by inhibiting key inflammatory signaling pathways, specifically NF-κB and IRF3, leading to a reduction in pro-inflammatory cytokines such such as IL-6, IL-8, COX-2, and iNOS. It also enhances the skin's intrinsic anti-inflammatory response by inhibiting the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme, which elevates local concentrations of cortisol. Furthermore, its antioxidant activity actively shields skin cells from oxidative stress.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
Specific clinical efficacy concentrations for Methyl Glycyrrhizate are not detailed in the available research, preventing an assessment of common dusting practices.
The Formula
Formulation
Stability
Methyl Glycyrrhizate, an ester of Glycyrrhizic Acid, exhibits excellent thermal stability, with related compounds showing stability from 100°C to 121°C across a pH range of 4.5 to 9.5. Its solubility is optimized in water, particularly warm water, and significantly improves above pH 4.5. It is not soluble in oily phases.
Conflicts
- High concentrations of glycyrrhetinic acid derivatives, including Methyl Glycyrrhizate, may exhibit cytotoxic effects in vitro.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Methyl Glycyrrhizate is safe for use in cosmetic and personal care products at current concentrations. It is poorly absorbed through the skin and is not considered an irritant, sensitizer, phototoxic agent, or photosensitizer. For ingredients derived from plant sources, the CIR advises limiting total PCB/pesticide contamination to not more than 40 ppm (with individual residues not exceeding 10 ppm), and restricting toxic metal levels to less than 3 mg/kg for arsenic, 0.002% for heavy metals, and 1 mg/kg for lead.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Methyl Glycyrrhizate is a valuable ingredient for soothing and protecting sensitive and irritated skin, underpinned by a clear anti-inflammatory mechanism, antioxidant benefits, and an excellent topical safety profile.
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