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METHYL GLUCOSE SESQUIISOSTEARATE.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMULSIFYING

Methyl Glucose Sesquiisostearate is a versatile non-ionic ester, primarily functioning as an effective emulsifier for stable oil-in-water formulations. It simultaneously acts as a skin-conditioning agent and emollient, contributing to improved skin hydration and barrier integrity.

Summary

Emulsifying Emollient Skin conditioning

Science

Mechanism of Action

This ingredient expertly blends oil and water to stabilize emulsions, preventing phase separation within cosmetic products. On the skin, it forms a protective layer that minimizes transepidermal water loss (TEWL), thereby enhancing moisture retention and fortifying the skin's lipid barrier. Additionally, it optimizes the tactile qualities and overall sensory experience of formulations.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

4%

Key findings

  1. 01 A 28-day clinical use test of a night cream containing 4% Methyl Glucose Sesquiisostearate demonstrated excellent cutaneous and cosmetic acceptability, with no reported signs of intolerance or significant aggravation.
  2. 02 In a Human Repeated Insult Patch Test (HRIPT), a night cream at a 4% concentration exhibited moderate skin compatibility. While slight erythema was noted in 3 subjects during the challenge phase, no allergic sensitization was induced upon repeated applications, confirming its general tolerance.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As a nonionic water-in-oil emulsifier with an HLB value of 6.6, Methyl Glucose Sesquiisostearate provides robust emulsification and stability even at low concentrations. It contributes to enhanced emulsion viscosity, potentially reducing the need for additional thickeners, and improves the structural integrity of molded stick products and multi-phase makeup formulations.

Synergies

  • Often used synergistically with PEG-20 Methyl Glucose Sesquiisostearate to create highly stable oil-in-water emulsions.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded Methyl Glucose Sesquiisostearate is safe as currently used in cosmetics. While a maximum use concentration of 1% was reported in lipstick applications, formulations up to 4% have been clinically evaluated for skin tolerance. Animal studies indicate the ingredient is non-irritating and non-sensitizing.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Methyl Glucose Sesquiisostearate is a valuable multifunctional ingredient, offering robust emulsification, significant skin conditioning, and emollient benefits with a favorable safety and compatibility profile across all skin types.

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