Science
Mechanism of Action
The ingredient functions by activating olfactory receptors, specifically OR2AT4, which are expressed in human skin. This activation has been shown to significantly reduce the release of IL-1beta-induced PGE2 in primary human fibroblasts, thereby indicating a localized anti-inflammatory effect on the skin.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In primary human fibroblasts, this compound significantly reduced IL-1beta-induced PGE2 release by activating olfactory receptors (OR2AT4) in human skin, suggesting utility in fighting inflammatory skin conditions.
- 02 In rat/mouse olfactory receptor neurons, it activated PLC at a concentration of 65 µM, illustrating its role in odorant-stimulated phosphoinositide signaling.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The compound is stable under normal handling and storage conditions. It is important to avoid direct sunlight and extreme temperatures, both high and low. While stable at a pH of 12.2, it exhibits poor stability in the presence of strong acids, strong bases, bleaches, and soaps. It maintains good stability in formulations such as body lotions, shampoos, and roll-on deodorants.
Conflicts
- strong bases
- strong acids
- sources of ignition
- direct sunlight
- bleaches
- soaps
Safety
Safety Profile
This ingredient is compliant with IFRA standards for fragrance use. Safety Data Sheets indicate a potential for skin and eye irritation, recommending washing with soap and water if skin contact occurs and seeking medical attention if irritation persists. It is incompatible with strong acids and bases.
Your Skin
Skin Compatibility
Our Assessment
Verdict
METHYL DIMETHYL-CYCLOHEXENYLMETHYLENEAMINO-BENZOATE is a valuable ingredient, providing not only perfuming qualities but also a unique anti-inflammatory mechanism through olfactory receptor activation in skin, warranting further exploration for targeted skincare applications.
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