Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

METHYL DIISOPROPYL PROPIONAMIDE.

Valuable CAS 51115-67-4 / FRAGRANCE

A synthetic cooling agent that provides a mild, long-lasting refreshing sensation to the skin without the irritation commonly associated with traditional coolants like menthol. It also functions as a skin conditioning agent, enhancing product texture and spreadability.

Summary

cooling agent masking skin conditioning

Science

Mechanism of Action

Methyl Diisopropyl Propionamide works by selectively interacting with thermoreceptors in the skin, delivering a gentle and sustained cooling effect without triggering an irritating response. Beyond its primary role, it conditions the skin for a smooth, silky feel and can contribute to improved stability and absorption of other active ingredients within a formulation.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–1%
Optimal

0.3%

Key findings

  1. 01 Recommended rates of use for desired cooling performance in products typically range from 0.1% to 0.5%.
  2. 02 A dosage of 1% is recommended in some specific formulations.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 9
0 7 14

Stability

The ingredient demonstrates robust stability across a wide pH range (4-9), showing minimal hydrolysis (<10% after 5 days at 50°C), equivalent to a half-life exceeding one year at 25°C. For optimal performance, store at room temperature, protected from heat and light. Avoid exceeding 80°C during the mixing phase.

Synergies

  • Enhances product spreadability
  • May improve stability and absorption of other active ingredients

Conflicts

  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally regarded as safe for use in cosmetic and personal care products. The Research Institute for Fragrance Materials (RIFM) concluded it does not pose a concern for skin sensitization and is not expected to be photoirritating or photoallergenic. While studies in rats indicated 'slight irritation to the skin' and 'harmful by the oral route,' acute toxic effects are not anticipated at typical topical use concentrations. For oral hygiene products, the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) found risk not unreasonable up to 0.052% in toothpastes and 0.009% in mouthwashes. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) gave a conditional acceptance for flavoring, requiring more data on potential in vivo genotoxicity and kidney effects at low doses, primarily relevant for ingestion.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Methyl Diisopropyl Propionamide is a valuable synthetic ingredient for delivering non-irritating, long-lasting cooling effects and improving skin feel across a wide range of skincare and personal care formulations.

Related

Similar Ingredients

Finding similar ingredients…