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METHOXYPHENYL MENTHANE CARBOXAMIDE.

Valuable / SKIN CONDITIONING

METHOXYPHENYL MENTHANE CARBOXAMIDE, frequently identified as WS-12, is a potent synthetic cooling agent designed for precise sensory effects. It delivers an intense and prolonged cooling sensation to the skin, uniquely achieving this without the characteristic minty aroma or flavor associated with traditional coolants like menthol.

Summary

Cooling Agent

Science

Mechanism of Action

WS-12 functions as a highly selective, high-affinity agonist for the transient receptor potential melastatin 8 (TRPM8) receptor, also known as the cold menthol receptor 1 (CMR1). By specifically activating these temperature-sensitive receptors within sensory neurons, it induces a perception of coldness on the skin without altering the actual skin temperature or engaging other thermo-sensitive TRP channels (TRPV1-4, TRPA1).

Research

Clinical Evidence

High confidence
Effective range 0.001–2%
Optimal

0.26%

Key findings

  1. 01 In *Xenopus* oocytes, WS-12 robustly activated TRPM8, demonstrating superior potency and efficacy compared to menthol, with an EC50 of approximately 12 µM.
  2. 02 At a concentration of 1 mM, WS-12 exhibited high selectivity, specifically avoiding activation of other thermo-sensitive TRP channels including TRPV1, TRPV2, TRPV3, TRPV4, and TRPA1.
  3. 03 Effective cooling intensity, characterized by a smooth sensory experience devoid of burning or tingling sensations, has been observed at concentrations as low as 0.001% to 0.01%.
  4. 04 General product formulations typically utilize physiological cooling agents within a 0.001% to 2% range, with preferred concentrations between 0.01% and 1.0%, and more preferably between 0.02% and 0.5%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

WS-12 demonstrates excellent thermal stability, maintaining its effectiveness in formulations even under high-temperature processing conditions, up to 200°C. It is insoluble in water but readily soluble in alcohol and DMSO.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While METHOXYPHENYL MENTHANE CARBOXAMIDE (WS-12) is recognized as a flavoring agent for food use by FEMA (4681) and JECFA (2079), its specific FDA status for cosmetic application is not explicitly detailed. It is noted to exhibit minimal irritation to the skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

METHOXYPHENYL MENTHANE CARBOXAMIDE is a valuable ingredient for precision skincare, offering highly effective, selective, and long-lasting cooling without the sensory drawbacks of traditional menthol.

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