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METHOXY PEG-144.

Valuable / NOT REPORTED

Methoxy PEG-144 is a versatile polyethylene glycol (PEG) derivative, primarily functioning as a humectant to retain moisture, an emollient to soften skin, an emulsifier to blend diverse ingredients, and a solvent to dissolve others, suitable for a broad array of skincare formulations.

Summary

humectant emulsifier emollient solvent

Science

Mechanism of Action

This derivative of polyethylene glycol (PEG) contributes multiple functionalities to skincare formulations. It acts as a humectant, effectively drawing and retaining moisture to boost skin hydration. As an emollient, it aids in conditioning the skin, contributing to a smoother texture. Its emulsifying properties are crucial for creating stable, homogeneous mixtures of water and oil-based components. Furthermore, Methoxy PEG-144 serves as a solvent, facilitating the dissolution and dilution of various other ingredients, and can enhance the skin's absorption of these additives.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 30% polyethylene glycol (PEG) vehicle, when utilized for salicylic acid peels, facilitated uniform exfoliation with minimal irritation, effectively preventing stinging and burning sensations. This application proved suitable for sensitive skin, leading to significant improvement in acne lesions without observed adverse effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7
0 7 14

Stability

Methoxypolyethylene glycols exhibit stability within a pH range of 5.5 to 7.0 at 25°C. While generally stable in both acidic and basic conditions, extreme concentrations may affect integrity. Stability is compromised by warm temperatures, light, and the presence of oxygen. Optimal shelf-life is achieved through storage at frozen (-20°C) or refrigerated (4°C) temperatures.

Conflicts

  • strong oxidizing agents
  • strong acids
  • strong bases
  • PVC (polyvinylchloride) tubing

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of methoxypolyethylene glycols, including this specific derivative, for their use in cosmetics. A 2016 CIR report notably removed previous advisories against using PEGs on compromised skin. However, concerns persist regarding potential contamination with impurities such as ethylene oxide and 1,4-dioxane for certain related PEG ingredients. While the broader PEG family is widely considered safe, there is an increasing recognition of allergic contact dermatitis associated with some PEG copolymers, suggesting a moderate sensitization risk.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Methoxy PEG-144 is a valuable, versatile ingredient for skincare, offering humectant, emollient, emulsifying, and solvent properties, supported by a generally favorable safety profile and broad skin compatibility.

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