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METHOXY-ISOPROPYL-METHYLCYCLOHEXENE.

Valuable CAS 14576-08-0 / PERFUMING

A synthetic, menthol-derived cooling agent designed to impart a rapid and prolonged refreshing sensation on the skin. It is recognized for its broad applicability across various cosmetic formulations.

cooling agent skin conditioning

Science

This compound, chemically identified as Menthyl Ethylamido Oxalate, functions by stimulating specific nerve endings within the skin. It modulates skin sensations and activates Transient Receptor Potential (TRP) channels, thereby altering the perception of temperature to create a cooling effect.


Research

High confidence
Effective range 0.2–1%
Optimal

0.5%

Key findings

  1. 01 Induces a noticeable cooling effect within 1 minute of application, persisting for up to 30 minutes, when used within a 0.2-1.0% concentration range.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Optimal stability is observed in formulations with an acidic to neutral pH. It demonstrates excellent thermal stability, enduring temperatures up to 70°C.


Safety

CIR Status
Not reviewed
Sensitization risk Low

Generally possesses a high safety profile for cosmetic use worldwide, with the exception of China. However, a black box warning advises caution to prevent irritation in sensitive areas such as the eyes. In its concentrated form, this ingredient may cause serious eye irritation and potential skin irritation, sun sensitivity, or allergic reactions.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

METHOXY-ISOPROPYL-METHYLCYCLOHEXENE is a highly effective, menthol-derived cooling agent, widely compatible with various skin types and offering a rapid, sustained refreshing sensation in numerous product applications.


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