Science
Mechanism of Action
This ingredient operates by signaling to the skin's intrinsic metabolic pathways, stimulating its endogenous repair mechanisms. Specifically, the SH-Oligopeptide-1 component, also recognized as Epidermal Growth Factor (EGF), interacts with epidermal growth factor receptors (EGFR) located on the surface of skin cells. This specific binding event initiates intracellular cascades that accelerate the proliferation of new skin cells and boost the synthesis of crucial structural proteins like collagen and elastin, which are fundamental for maintaining skin firmness and elasticity. Concurrently, it supports skin regeneration, aids in wound healing processes, diminishes the appearance of wrinkles, refines skin tone, and enhances blood vessel formation. The SH-Polypeptide-7 component functions primarily as a skin conditioning agent.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The Oligopeptide-1 (sh-Oligopeptide-1/EGF) component is highly susceptible to pH fluctuations and enzymatic degradation by microorganisms, which can lead to a significant loss of activity. To ensure optimal stability and efficacy, maintaining a pH range of 5.0 to 8.0 is critical, and stringent measures to prevent microbial contamination are essential during formulation.
Safety
Safety Profile
The complete ingredient, METHIONYL SH-POLYPEPTIDE-7 ALANYL SR-SPIDER OLIGOPEPTIDE-1, has not undergone specific safety review or rating by CIR or SCCS. For sh-Oligopeptide-1, it is authorized as a cosmetic but carries unknown long-term risks. It is important to distinguish that active EGF is considered a potent, unauthorized drug, and sh-Oligopeptide-1 does not function as a medical treatment equivalent of EGF.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While a clinical study suggests benefits in skin rejuvenation and texture improvement, a critical review raises significant concerns regarding the scientific validation of its efficacy and highlights unknown long-term risks, requiring careful consideration for its application.
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