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METHIONYL SH-POLYPEPTIDE-4 DECAPEPTIDE-40.

Valuable / ANTIOXIDANT

METHIONYL SH-POLYPEPTIDE-4 DECAPEPTIDE-40 is an advanced recombinant fusion peptide engineered to visibly enhance skin condition, provide robust antioxidant defense, and offer comprehensive protection against environmental stressors. It actively supports skin rejuvenation, contributing to smoother texture, increased suppleness, and the visible reduction of wrinkles.

Summary

Antioxidant Skin Conditioning Skin Protecting Anti-aging

Science

Mechanism of Action

This single-chain recombinant fusion peptide is produced through fermentation in E. coli, integrating sh-polypeptide-4 and decapeptide-40. It functions primarily as a skin conditioning agent, optimizing skin hydration, promoting a smoother feel, and refining overall appearance. As a potent antioxidant, it neutralizes free radicals, thereby inhibiting oxidative processes that can degrade skin components. Additionally, it forms a protective barrier on the skin's surface, mitigating the penetration of harmful substances and reducing the impact of external aggressors like pollution and UV radiation. As a peptide, it also signals the skin to activate its endogenous repair mechanisms, fostering healthier, more youthful skin by enhancing texture, improving suppleness, and stimulating the regeneration of mature skin cells to strengthen dermal structure and visibly reduce the appearance of wrinkles.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data suggesting this ingredient is commonly used at sub-efficacious concentrations.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

As a complex peptide, METHIONYL SH-POLYPEPTIDE-4 DECAPEPTIDE-40 is sensitive to minute alterations in solution chemistry, exhibiting optimal stability within a relatively narrow pH range. The presence of specific amino acids, such as methionine, cysteine, histidine, tryptophan, and tyrosine, renders it susceptible to oxidative damage. This oxidation can induce changes in the peptide's physiochemical characteristics, potentially leading to aggregation or fragmentation and compromising its efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Formal safety assessments by regulatory bodies such as CIR, SCCS, or FDA for METHIONYL SH-POLYPEPTIDE-4 DECAPEPTIDE-40 are currently unavailable. While adverse reactions are generally uncommon, a preliminary patch test is recommended prior to extensive application of any new product containing this ingredient to confirm individual compatibility.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

METHIONYL SH-POLYPEPTIDE-4 DECAPEPTIDE-40 is a valuable, multifunctional peptide offering significant skin conditioning, antioxidant protection, and anti-aging benefits, compatible with all skin types; however, specific clinical efficacy data and formal safety assessments are currently limited.

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