Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

METHIONYL SH-POLYPEPTIDE-14 DECAPEPTIDE-40.

Insufficient Data / ANTIOXIDANT

METHIONYL SH-POLYPEPTIDE-14 DECAPEPTIDE-40 is a sophisticated peptide designed to offer a multi-pronged approach to skin health, acting as an antioxidant, skin conditioner, and protectant. It signals the skin's endogenous repair mechanisms, actively targeting visible signs of aging by enhancing collagen synthesis and potentially increasing facial volume. Furthermore, it contributes to improved skin resilience by supporting muscle tone and mimicking the action of certain neuromodulators.

Antioxidant Skin conditioning Skin protectant Anti-aging Collagen synthesis booster Skin plumping/volumizing Muscle tone enhancer Wrinkle reduction

Science

This peptide functions as an effective antioxidant, inhibiting oxygen-promoted reactions and safeguarding ingredient stability while protecting skin from oxidative stress. It conditions the skin, leading to a softer, smoother, and more hydrated complexion, thereby enhancing overall skin appearance and texture. Additionally, it forms a protective barrier on the skin's surface, reducing the impact of external aggressors like pollution and UV radiation and preventing the penetration of harmful substances. As a signaling peptide, it activates the skin's inherent repair mechanisms. Research indicates its capacity to inhibit noradrenaline release and significantly increase collagen synthesis, crucial for maintaining skin structure. It can also augment lipid content in adipose cells, potentially contributing to increased facial volume. Functionally, it acts as a skin anti-aging agent by mimicking the neuronal exocytosis inhibition characteristic of Botulinum toxins. Moreover, it upregulates muscleblind-like 1 (MBNL-1) expression, an RNA-binding protein vital for the trans-differentiation of fibroblasts to myofibroblasts, which is highly relevant for addressing skin's loss of muscle tone associated with aging.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

METHIONYL SH-POLYPEPTIDE-14 DECAPEPTIDE-40 currently lacks specific safety assessments from major regulatory bodies such as CIR, SCCS, or FDA. While it is not yet rated by some industry teams, a closely related peptide, R-(Sh-Polypeptide-2 Decapeptide-40), has been noted to potentially cause skin irritation, redness, and allergic reactions. Data concerning the topical usage of related peptides during pregnancy and breastfeeding is also currently unavailable.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

Despite promising multi-functional mechanisms, comprehensive clinical efficacy data and specific safety assessments for METHIONYL SH-POLYPEPTIDE-14 DECAPEPTIDE-40 are currently limited, warranting further research for definitive adoption.


Related

Finding similar ingredients…