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METHIONYL SH-POLYPEPTIDE-11 DECAPEPTIDE-40.

Valuable / ANTIOXIDANT

METHIONYL SH-POLYPEPTIDE-11 DECAPEPTIDE-40 is an advanced, skin-permeable growth factor and peptide complex engineered to selectively deliver active substances to the deep dermis. It functions as a potent bioregenerator, enhancing skin elasticity, texture, and supporting wound healing processes.

Summary

Skin-Conditioning Agent Skin Protecting Anti-aging Wound healing Collagen boosting Elastin boosting Skin regeneration Wrinkle reduction Hair growth promoting

Science

Mechanism of Action

This complex targets the deep dermal layers, primarily through its sh-Polypeptide-11 component, which acts as Acidic Fibroblast Growth Factor (aFGF). It actively stimulates the proliferation and growth of dermal cells, particularly fibroblasts, thereby upregulating collagen and elastin synthesis for a visibly uplifted and firm appearance. Beyond structural support, it promotes comprehensive skin regeneration, accelerates wound healing, enhances primary hair cell proliferation, and improves hair strength. Furthermore, it boosts vascularization and blood circulation via endothelial cell proliferation and provides robust antioxidant protection by neutralizing free radicals, thus decelerating cellular aging.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Human application tests confirm effects such as improved nasolabial folds, enhanced skin elasticity, and refined skin texture.
  2. 02 Topical administration of its sh-Polypeptide-11 component (rh-aFGF) has been shown in randomized, multicenter, double-blind, and placebo-controlled clinical trials to accelerate dermal wound healing and shorten recovery periods by stimulating fibroblast and keratinocyte proliferation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Conflicts

  • Its large molecular weight necessitates the use of advanced carrier systems, such as lipid spheres, to effectively facilitate penetration beyond the stratum corneum and reach target dermal layers.

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Low

While sh-Polypeptide-11, a key component, is widely regarded as safe, effective, and skin-compatible across high-end anti-aging and hair care applications, formal CIR, SCCS, or FDA regulatory status specifically for the complete METHIONYL SH-POLYPEPTIDE-11 DECAPEPTIDE-40 complex is not publicly documented.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

METHIONYL SH-POLYPEPTIDE-11 DECAPEPTIDE-40 is a highly valuable ingredient for advanced skincare, demonstrating significant efficacy in anti-aging, skin regeneration, and wound healing through its potent growth factor and peptide actions.

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