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Moumoujus

METHIONYL SH-POLYPEPTIDE-11.

Valuable / SKIN CONDITIONING

METHIONYL SH-POLYPEPTIDE-11 is a sophisticated synthetic recombinant peptide, engineered as an analog of acidic Fibroblast Growth Factor (aFGF or FGF1). It functions as a potent cell signaling molecule, stimulating dermal cell proliferation to enhance the synthesis of collagen and elastin. This action leads to visibly firmer, more resilient skin and augments the skin's natural defense mechanisms.

Summary

Skin regenerating Anti-aging Wound healing Boosts collagen production Boosts elastin production Stimulates fibroblast proliferation Stimulates keratinocyte proliferation Antioxidant Reinforces skin's natural defenses Minimizes fine lines and wrinkles

Science

Mechanism of Action

This peptide operates as a crucial cell signaling molecule, mimicking the biological activity of natural acidic Fibroblast Growth Factor (FGF1). Its primary function involves stimulating the proliferation and growth of dermal cells, particularly fibroblasts, which are vital for producing collagen and elastin. This stimulation significantly improves skin firmness, elasticity, and visibly diminishes the appearance of fine lines and wrinkles. Furthermore, it strengthens the skin's inherent defense mechanisms and offers potent antioxidant protection by neutralizing free radicals, thereby mitigating cellular aging. Due to its substantial molecular size, effective penetration beyond the stratum corneum necessitates advanced delivery systems, such as liposomes. It is classified as mitogenic, promoting cell multiplication, but not mutagenic.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of rh-aFGF, an analog of METHIONYL SH-POLYPEPTIDE-11, has been shown in randomized, multicenter, double-blind, and placebo-controlled clinical trials to accelerate wound healing and shorten recovery periods.
  2. 02 An in-vitro study demonstrated that recombinant FGF-1, another analog, strongly stimulated both fibroblast and keratinocyte proliferation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 7 – 8
0 7 14

Stability

Optimal stability and solubility are achieved within a narrow pH range of 7.0 to 8.0. Exposure to pH below 7.0 (e.g., 5.5) or prolonged exposure above 8.0 should be strictly avoided to prevent destabilization. As a methionine-containing peptide, it is susceptible to oxidation; incorporating additional methionine may enhance stability. Degradation can also occur via hydrolysis and deamidation. Solutions require frozen storage in single-use aliquots to mitigate freeze-thaw degradation and minimize oxygen exposure.

Synergies

  • Liposomal encapsulation for enhanced epidermal penetration

Conflicts

  • Strong acids (pH < 7.0)
  • Strong bases (pH > 8.0)
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Although the Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed METHIONYL SH-POLYPEPTIDE-11 by name, it is generally recognized as a safe and skin-compatible recombinant human peptide, produced through E. Coli fermentation. EWG notes that products certified as EWG VERIFIED cannot contain this ingredient without specific, adequate substantiation. SkinSAFE classifies products containing sh-Polypeptide-11 as 'Irritant Free'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

METHIONYL SH-POLYPEPTIDE-11 is a valuable recombinant peptide that functions as a powerful cell signaling molecule to regenerate skin, boost collagen and elastin synthesis, and provide antioxidant protection.

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