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Moumoujus

METHIONYL SH-POLYPEPTIDE-1.

Insufficient Data / SKIN CONDITIONING

METHIONYL SH-POLYPEPTIDE-1 is a sophisticated synthetic peptide designed to mimic basic Fibroblast Growth Factor (bFGF), a critical cellular signaling molecule. It actively stimulates cellular proliferation and migration, aiming to revitalize skin and enhance its structural integrity. This ingredient supports improved skin elasticity, reduced wrinkle appearance, and robust hydration.

Summary

Anti-aging Wrinkle Reduction Skin Elasticity Improvement Skin Firmness Skin Renewal Tissue Regeneration Wound Healing Hydration (indirectly via HA synthesis) Hair Growth Stimulation Melanocyte Migration/Re-pigmentation

Science

Mechanism of Action

This single-chain synthetic peptide operates by mimicking bFGF, functioning as a potent mitogen. It primarily stimulates the proliferation, growth, and migration of fibroblasts, the cells responsible for synthesizing vital structural proteins such as collagen and elastin. By boosting the production of these proteins, it contributes to enhanced skin elasticity and a reduction in visible wrinkles. Additionally, it interacts synergistically with other growth factors like Epidermal Growth Factor (EGF) and Insulin-like Growth Factor-1 (IGF-1) to significantly increase hyaluronic acid synthesis, promoting smoother, more hydrated skin. Its influence extends to regulating factors involved in blood vessel development and promoting melanocyte migration, indicating roles in epidermal renewal, tissue regeneration, wound healing, and potential re-pigmentation.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Typically supplied as a stable, soluble lyophilized powder, METHIONYL SH-POLYPEPTIDE-1 is a relatively large molecule often requiring advanced delivery systems like liposomes or PLGA-coated nanoparticles for optimal topical penetration and efficacy. The methionine component is prone to oxidation, particularly in alkaline environments (pH 8 or higher), necessitating the inclusion of antioxidants in formulations to preserve its integrity.

Synergies

  • Epidermal Growth Factor (EGF)
  • Insulin-like Growth Factor-1 (IGF-1)
  • Antioxidants (for stability)

Conflicts

  • Alkaline pH (around 8 and higher)
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Direct comprehensive safety assessments by regulatory bodies such as CIR, SCCS, or FDA specifically for METHIONYL SH-POLYPEPTIDE-1 are not available. While studies on a closely related bFGF analog, sh-Polypeptide-1, indicated no irritation or general toxicity following topical application, it is crucial to note that basic Fibroblast Growth Factor (bFGF) itself has been implicated in melanoma progression. This association suggests that bFGF-mimetic ingredients warrant a cautious approach.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

METHIONYL SH-POLYPEPTIDE-1 offers a potent mechanistic profile for skin rejuvenation and repair; however, specific clinical efficacy data for this exact ingredient and quantitative safety parameters are currently insufficient to provide a definitive recommendation.

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