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METHIONYL SH-OLIGOPEPTIDE-75 SH-OLIGOPEPTIDE-2.

Valuable / ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

METHIONYL SH-OLIGOPEPTIDE-75 SH-OLIGOPEPTIDE-2 is an advanced synthetic polypeptide engineered to functionally mimic Insulin-like Growth Factor-1 (IGF-1). This sophisticated ingredient is meticulously designed to stimulate cellular regeneration and collagen synthesis, profoundly enhancing skin elasticity and overall vitality.

Summary

Antioxidant Skin-conditioning Skin protecting Stimulates cell proliferation Promotes wound healing Anti-aging Enhances collagen synthesis Strengthens skin barrier Boosts hyaluronic acid biosynthesis Improves skin elasticity Minimizes fine lines and deep wrinkles

Science

Mechanism of Action

This ingredient functions as a synthetic analog of Insulin-like Growth Factor-1 (IGF-1), a crucial single-chain polypeptide hormone. Its action involves the strategic activation of cellular signaling within the AKT pathway, a cascade vital for cellular regeneration, anti-aging processes, and efficient wound healing. When applied topically, it significantly boosts the biosynthesis of critical extracellular matrix components, including hyaluronic acid, leading to a visibly smoother, more youthful complexion. Furthermore, it actively promotes collagen production and fortifies the skin barrier, effectively diminishing the appearance of fine lines and deep wrinkles.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Research on sh-Oligopeptide-2 (IGF-1), a key component of this ingredient, demonstrates its capacity to stimulate fibroblast proliferation and collagen synthesis, thereby enhancing skin elasticity and hydration. It actively promotes cell proliferation and tissue repair by binding to specific skin cell receptors to initiate collagen production.
  2. 02 Studies also indicate that sh-Oligopeptide-2 (IGF-1) operates synergistically with Epidermal Growth Factor (sh-Oligopeptide-1) to promote robust keratinocyte (skin cell) proliferation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Synergies

  • Synergistic with sh-Oligopeptide-1 (EGF) for enhanced keratinocyte proliferation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The specific ingredient METHIONYL SH-OLIGOPEPTIDE-75 SH-OLIGOPEPTIDE-2 has not undergone a direct review by the Cosmetic Ingredient Review (CIR) Expert Panel. However, its core component, sh-Oligopeptide-2 (IGF-1), is generally recognized as a safe cosmetic ingredient, with regulatory bodies such as the European Cosmetics Directive acknowledging its safety. While serious side effects are rare, individuals predisposed to dermatological issues or allergic reactions should perform patch testing. A critical caution exists for growth factor-mimicking peptides like IGF-1 due to a potential correlation with tumorigenesis or progression; therefore, individuals at risk of skin cancer or psoriasis are advised to avoid use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This advanced peptide offers significant benefits for anti-aging and skin regeneration through its IGF-1 mimicking action, promoting elasticity and reducing wrinkles, though specific caution is warranted for individuals at risk of certain skin conditions.

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