Science
Mechanism of Action
This peptide functions by binding to specific Epidermal Growth Factor Receptors (EGFRs) present on skin cells, which activates intracellular signaling pathways. This activation accelerates the production of new skin cells and boosts the synthesis of essential structural components like collagen and elastin, promoting comprehensive skin repair and enhanced self-regeneration. Its actions extend to stimulating keratinocyte proliferation, improving skin barrier function, and moderating inflammatory reactions, contributing to scar reduction and sustained moisturization.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Clinical observations involving sh-Oligopeptide-1 (EGF) have indicated benefits in wound healing for diabetic patients post-laser treatment and in managing senile purpura.
- 02 A topical EGF serum, when applied twice daily for 8 weeks, resulted in a decrease in melasma for 73% of subjects, though specific concentrations were not reported.
- 03 A systematic review conducted in 2021 suggested that sh-Oligopeptide-1 can expedite wound healing, act as a hyperpigmentation reducer, and possess anti-inflammatory properties that may alleviate acne lesions.
- 04 However, a critical review concluded that clinical studies for sh-oligopeptide-1, when considered as functional recombinant human EGF (hr-EGF) in cosmetic applications, lack a robust scientific basis, with unproven preclinical bioactivity.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The full ingredient METHIONYL SH-OLIGOPEPTIDE-1 SR-JELLYFISH POLYPEPTIDE-1 has insufficient data regarding its CIR status. For its component, sh-Oligopeptide-1 (EGF), there are cautionary notes due to its classification as a 'growth factor.' Overexpression or dysregulation of growth factors carries a potential risk for tumorigenesis, as EGF signaling is frequently observed in tumor cells. Therefore, careful consideration is advised for personal care applications that mimic growth factors. While sh-EGF is authorized in various concentrations for general cosmetic use, long-term risks remain undefined, and its preclinical bioactivity for cosmetic purposes has not been definitively proven. Furthermore, active EGF is recognized as a potent unauthorized drug, rather than a cosmetic ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its potential to support skin regeneration and address signs of aging, the ingredient's nature as a growth factor warrants significant caution due to potential tumorigenesis risks, and its efficacy as a cosmetic ingredient lacks robust scientific validation.
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