Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

METHIONYL R-SALMON OLIGOPEPTIDE-1 SH-POLYPEPTIDE-8.

Insufficient Data / ANTIOXIDANT, SKIN PROTECTING

METHIONYL R-SALMON OLIGOPEPTIDE-1 SH-POLYPEPTIDE-8 is an advanced recombinant fusion peptide engineered to promote skin repair and regeneration. It synergistically combines antioxidant activity with potent growth factor signaling to enhance cellular proliferation and strengthen the skin's structural components.

Summary

Antioxidant Skin protection Cell proliferation Cell differentiation Cell migration Hyaluronic acid synthesis booster Wound healing acceleration Skin barrier improvement Anti-inflammatory Scar reduction Collagen synthesis booster Elastin synthesis booster Anti-aging Firming Hydration

Science

Mechanism of Action

This fusion peptide exerts its effects through a tripartite mechanism. R-SALMON OLIGOPEPTIDE-1 functions as an antioxidant and skin protectant, stimulating the skin's natural reparative processes. SH-OLIGOPEPTIDE-1, known as Epidermal Growth Factor (EGF), binds to its receptor (EGFR) to significantly boost cell survival, differentiation, and the proliferation and migration of keratinocytes and fibroblasts. This action leads to increased hyaluronic acid production, improved skin barrier function, accelerated wound healing, suppressed inflammation, and reduced scar formation. Complementing this, SH-POLYPEPTIDE-8, or Platelet Derived Growth Factor (PDGF), further stimulates fibroblast growth and the synthesis of critical extracellular matrix components, including collagen and elastin.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety evaluations by major regulatory bodies like CIR, SCCS, or FDA for Methionyl R-Salmon Oligopeptide-1 SH-Polypeptide-8 are not detailed in the provided research. While its component, sh-Oligopeptide-1 (EGF), is authorized for cosmetic use at various concentrations, long-term risks remain unspecified. Concerns exist regarding the mitogenic properties (cell proliferation stimulation) of growth factors and their theoretical link to cancer; however, experts generally distinguish EGF as mitogenic but not mutagenic (not inducing genetic mutations leading to cancer).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While the ingredient's component growth factors demonstrate a strong mechanistic basis for promoting skin regeneration and repair, the absence of specific clinical efficacy and comprehensive safety data for this particular fusion peptide necessitates further investigation.

Related

Similar Ingredients

Finding similar ingredients…