Science
Mechanism of Action
Methionyl r-Clostridium Botulinum Polypeptide-1 Hexapeptide-40 is a synthetic, single-chain recombinant fusion peptide bio-engineered through E. coli fermentation. It incorporates a specialized Macromolecule Transmission Domain (MTD) which significantly enhances its transdermal delivery across the stratum corneum and into deeper skin and nerve cells. By mimicking the Botulinum light chain, it precisely targets SNAP-25, a crucial component of the SNARE complex, thereby inhibiting acetylcholine release. This action induces muscle relaxation, directly reducing the appearance of expression lines and wrinkles. Beyond neuromodulation, the peptide also stimulates intrinsic cellular repair pathways, fosters regeneration of mature skin, and reinforces the skin's supportive structure, leading to improved skin health and firmness.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Daily application of a mask containing the ingredient for 4 hours demonstrated significant improvements in facial and fine wrinkles, alongside enhanced skin density and elasticity. These positive effects were particularly pronounced in women within the 40-50 age bracket.
- 02 A transdermal diffusion study, utilizing a Strat-M membrane, confirmed the continuous and sustained penetration of the peptide into the skin over a 24-hour period.
- 03 Broader studies on topical botulinum neurotoxin A (BoNTA) formulations, which this peptide emulates, have consistently shown efficacy in diminishing fine lines, wrinkles, and reducing sweating patterns through multiple applications, with robust tolerability and no reported long-term adverse events.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal stability is observed in buffered liquid formulations within a pH range of 5.4 to 5.8, ideally centered around pH 5.5–5.6. Under refrigeration (0–10°C), stability is maintained for at least one year, while at room temperature (10–30°C), it remains stable for a minimum of six months. Broader stability for related botulinum toxin types has been noted between pH 2.7 and 10.2.
Safety
Safety Profile
Registered on the International Cosmetic Ingredient Dictionary (ICID) in December 2014, classifying it as a cosmetic raw material distinct from medical-grade botulinum toxins. Comprehensive raw material safety evaluations include tests for cell toxicity, bacterial reverse mutation, chromosomal aberrations, skin irritation (EPISKIN), eye irritation (EpiOcular), and skin sensitization (Local Lymph node Assay), all conducted without animal testing, suggesting a favorable safety profile for cosmetic application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This innovative peptide represents a valuable active for precision skincare, offering a topical, non-invasive solution to visibly reduce expression lines and enhance global skin health through its unique mechanism of muscle relaxation and regenerative signaling.
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References
Sources