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Moumoujus

METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-OLIGOPEPTIDE-1.

Insufficient Data / SKIN CONDITIONING

This ingredient is a complex single-chain recombinant fusion peptide designed to act as a precision skin conditioning agent. Its key component, rh-Oligopeptide-1 (also known as Epidermal Growth Factor or EGF), is pivotal in stimulating cellular growth, proliferation, and renewal for enhanced skin health.

Summary

Skin conditioning Wound healing Skin renewing Anti-aging Moisturizing Evens skin tone Anti-blemish

Science

Mechanism of Action

This recombinant fusion peptide operates by signaling the skin to activate its natural repair mechanisms, promoting the endogenous production of vital proteins like collagen. Specifically, its rh-Oligopeptide-1 (EGF) component functions as a critical cellular signal, stimulating epidermal cell growth, proliferation, and differentiation, which supports wound healing and skin renewal. This intricate action contributes to strengthening skin structure, enhancing firmness and elasticity, and visibly reducing the appearance of wrinkles associated with aging.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Direct clinical studies specifically addressing METHIONYL HEXAPEPTIDE-40 SH-DECAPEPTIDE-1 TRIPEPTIDE-44 RH-OLIGOPEPTIDE-1 are currently limited. However, a 2012 study on a serum containing a related barley-bioengineered epidermal growth factor (sh-Oligopeptide-1) demonstrated statistically significant improvements in fine lines, rhytids, skin texture, pore size, and dyschromatic conditions within one month, with sustained improvements over three months. Data on other individual peptides, such as Palmitoyl Tripeptide-1, indicates efficacy at concentrations as low as 0.0004% (4 ppm), showing a 4% increase in skin thickness.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH 5 – 8
0 7 14

Stability

The Oligopeptide-1 component exhibits high pH sensitivity, requiring final product pH to be precisely adjusted between 5.0 and 8.0 prior to its incorporation. To preserve its activity, strict measures against microbial contamination are essential, as enzymatic degradation can lead to a loss of efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

This ingredient is recognized in the European Commission's CosIng database for its skin conditioning function under Cosmetics Regulation provisions II/416, without specific SCCS opinions. Neither the full ingredient nor its key sh-Oligopeptide-1 (EGF) component has undergone formal review by the Cosmetic Ingredient Review (CIR) or received specific FDA status. While sh-Oligopeptide-1 is authorized for cosmetic use at various concentrations, its long-term safety risks remain unknown, and its preclinical bioactivity has been questioned in some reviews. Concerns exist that truly active EGF might be classified as an unauthorized drug rather than a cosmetic.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While demonstrating a promising mechanism for skin renewal and anti-aging via its EGF component, the overall efficacy and safety profile of this specific fusion peptide requires more direct clinical research and safety evaluations.

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