Science
Mechanism of Action
This extract operates by directly neutralizing diverse free radicals, including DPPH, superoxide anion, and hydroxyl radicals, which significantly reduces intracellular reactive oxygen species (ROS) accumulation and prevents lipid peroxidation. It also exerts anti-inflammatory effects and possesses broad-spectrum antimicrobial activity against both bacteria and fungi. These multifaceted actions are attributed to its rich composition of bioactive compounds, notably polyphenols (such as rutin, quercetin, and gallic acid) and various terpenoids.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 At 25 µg/mL, it demonstrated cytoprotective effects against hydrogen peroxide-induced cellular toxicity in PC12 neuronal cells.
- 02 Concentrations up to 200 µg/mL showed dose-dependent inhibition of reactive oxygen species (ROS)-induced oxidation in PC12 neuronal cells.
- 03 An ethyl acetate extract exhibited significant free radical scavenging activity (DPPH assay) with an IC50 of 14.24 µg/mL, outperforming BHA (IC50 = 18.27 µg/mL).
- 04 MIC values ranging from 250 to 4000 µg/mL indicated antidermatophytic (antifungal) effects against various Trichophyton and Microsporum species.
- 05 Extracts demonstrated antibacterial effects with MIC values between 250 and <2000 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The ingredient's polyphenolic compounds suggest amphiphilic properties, allowing for antioxidant activity in both aqueous and lipid formulation phases. Extracts are prepared using diverse solvents, including water and various organic solvents, indicating a broad range of soluble components. While explicit cosmetic pH stability data is not provided, general protection from oxidation is recommended to preserve the activity of its beneficial antioxidant compounds. Related studies show optimal pH for other applications around 2.5-3.5.
Safety
Safety Profile
In vitro studies have indicated low toxicity, with normal cells (COS7) showing no significant adverse effects at 50 µg/mL and PC12 neuronal cells tolerating up to 200 µg/mL of leaf extracts. Historically, the leaves and bark have a documented history of use in Chinese folk medicine for various dermatic conditions, suggesting a traditional safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Metasequoia Glyptostroboides Extract is a versatile botanical ingredient offering potent antioxidant, anti-inflammatory, and antimicrobial benefits, making it a valuable asset for comprehensive skin protection and health.
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References
Sources