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Moumoujus

MENTHONE GLYCERIN ACETAL.

Valuable CAS 63187-91-7 / REFRESHING

Menthone Glycerin Acetal is a nature-identical derivative of menthol designed to activate the skin's TRPM8 receptors, delivering a sustained and refreshing cooling sensation. It provides an immediate and long-lasting cooling effect, notably gentler and less irritating than traditional menthol, making it particularly suitable for sensitive skin types.

Summary

cooling agent refreshing

Science

Mechanism of Action

This ingredient functions by specifically activating the TRPM8 receptor, a key sensory channel in the skin responsible for perceiving cold. This targeted activation produces an immediate, refreshing, and prolonged cooling effect. Its soothing properties can help calm irritated and sensitive skin while supporting the integrity of the natural skin barrier.

Research

Clinical Evidence

High confidence
Effective range 0.1–30%
Optimal

5%

Key findings

  1. 01 At concentrations between 0.1% and 2%, Menthone Glycerin Acetal delivers a strong, persistent cooling sensation for up to 25 minutes.
  2. 02 A 1% concentration provides a cooling and freshness sensation comparable to 0.5% menthol, while being demonstrably gentler and non-irritating.
  3. 03 For maximum and extended cooling, lasting 2-3 hours, a 5% concentration is recommended, particularly when formulated in an Ethyl Alcohol or Ethoxydiglycol base.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 6.5 – 12
0 7 14

Stability

Optimal stability and efficacy are maintained within a broad pH range of 6.5 to 12. The ingredient is stable under recommended storage conditions, but exposure to high temperatures (above 80°C) should be avoided to prevent decomposition and volatilization. It is primarily oil-soluble, with good solubility in alcohol and glycols, but possesses limited water solubility (not exceeding 0.12%). It should not be applied undiluted to the skin.

Synergies

  • Ethyl Alcohol base for enhanced and prolonged cooling effect
  • Ethoxydiglycol base for enhanced and prolonged cooling effect

Conflicts

  • strong oxidizing agents
  • heat above 80°C

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

While Menthone Glycerin Acetal itself has not been reviewed by the CIR Expert Panel, its component Glycerin is considered safe for cosmetic use. Data from the Research Institute for Fragrance Materials (RIFM) indicate no concerns regarding skin sensitization, genotoxicity, photoirritation, or photoallergy at typical use levels. A calculated Margin of Exposure (MOE) greater than 100 for repeated dose toxicity further supports its safety. SkinSAFE classifies it as 'Irritant Free' and free from common allergens like parabens, sulfates, and dyes. Although safety data sheets for the concentrated raw material may suggest irritation, it is widely recognized as non-irritating and gentler than menthol in cosmetic formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Menthone Glycerin Acetal is a valuable cooling agent, offering a gentle yet long-lasting refreshing sensation that is well-suited for all skin types, including sensitive.

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