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Moumoujus

MENAQUINONE-7.

Valuable CAS 2124-57-4 / ANTI-SEBUM, ASTRINGENT, BLEACHING, SKIN PROTECTING, UV FILTER

Menaquinone-7, a distinct form of Vitamin K2, is a versatile ingredient that offers multiple benefits for skin health. It is valued for its capacity to protect the skin from oxidative damage, improve skin elasticity, and support efficient skin repair mechanisms.

Summary

Antioxidant Skin-Protecting Skin Brightening Anti-acne Astringent UV Filter

Science

Mechanism of Action

This ingredient functions as a powerful antioxidant, actively mitigating oxidative stress by reducing reactive oxygen species and inhibiting free radical accumulation within cells. It plays a role in tissue renewal and cell growth through the vitamin K-dependent growth-arrest specific gene 6 (Gas6) pathway. Menaquinone-7 also exhibits anti-inflammatory properties, contributes to accelerated wound healing, aids in scar minimization, and promotes a more uniform skin tone. Its sebum-regulating attributes help manage skin oiliness and reduce acne-contributing bacteria. Furthermore, it may stimulate the production of collagen and elastin, crucial proteins for maintaining skin's structural integrity and reducing the appearance of wrinkles.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A pilot study in 2015 by Nakamura et al. demonstrated that topical application of Vitamin K2-7 improved both skin elasticity and roughness.
  2. 02 In a randomized, double-blind, placebo-controlled trial in 2014, Theuwissen et al. observed that Menaquinone-7 (Vitamin K2) enhanced skin elasticity.
  3. 03 A 2019 randomized controlled trial highlighted that topical Vitamin K significantly increased wound contraction and improved healing rates, with statistically significant results evident from the seventh day compared to a control group.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data provided to assess common dusting practices or specific dusting thresholds for topical Menaquinone-7.

The Formula

Formulation

Solubility
Oil
Optimal pH 3.5 – 6.5
0 7 14

Stability

Menaquinone-7 exhibits optimal stability within a pH range of 3.5 to 6.5, becoming unstable in alkaline environments. It tolerates heat up to 90°C but should avoid higher temperatures. Enhanced purity correlates with improved stability within formulations. Protection from light is crucial for maintaining ingredient integrity.

Conflicts

  • Alkaline conditions
  • Minerals (e.g., magnesium oxide, calcium salts)
  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
375 µg/day (oral)%
Sensitization risk Low

Menaquinone-7 (MK-7) is generally recognized as safe (GRAS) by the FDA for specific oral nutritional beverage uses in children. The US Pharmacopeial Convention and Council for Responsible Nutrition (CRN) have established safety profiles and a Highest Observed Intake (HOI) of 375 µg/day for oral consumption in adults, noting general tolerability with mild digestive or allergic reactions possible with overdose. However, these comprehensive safety assessments predominantly pertain to oral intake, and a detailed review of its topical cosmetic use by organizations like CIR or SCCS is not yet available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Menaquinone-7 offers significant potential for enhancing skin elasticity, promoting healing, and providing antioxidant protection, making it a valuable addition to targeted skincare formulations, especially given its low irritancy and comedogenicity profile.

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