Science
Mechanism of Action
Melilotus Officinalis Leaf Extract exerts its effects by modulating inflammatory pathways, specifically inhibiting the synthesis and release of inflammatory mediators. It enhances microcirculation and reduces capillary permeability, facilitating the absorption of edema fluid and improving tissue oxygenation. Rich in phenolic compounds, it provides antioxidant protection, while coumarins contribute to its mild anticoagulant and anti-edema actions. Furthermore, it stimulates fibroblast growth and collagen production, inhibits collagenase, and possesses astringent qualities that tighten and tone the skin.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 A gel formulation containing 2% Melilotus Officinalis Leaf Extract demonstrated significant inflammation reduction, comparable to hydrocortisone, in a rat model. This formulation also exhibited no adverse skin reactions, suggesting excellent topical safety.
- 02 In vitro studies indicate that the ethanolic extract stimulates skin cell proliferation and tissue regeneration, prevents skin aging, increases fibroblast growth rate, inhibits collagenase, and promotes fibroblast collagen production. A notable lipolytic effect was also observed.
Transparency
Dusting Analysis
Melilotus Officinalis Leaf Extract is valued for its established biological activities and clinical potential, such as anti-inflammatory effects observed at 2% in animal models and various in vitro regenerative properties. Its inclusion in formulations is typically driven by these functional benefits rather than solely for marketing claims at sub-efficacious levels.
The Formula
Formulation
Stability
Semi-solid formulations containing Melilotus Officinalis Leaf Extract, with pH values ranging from 5.15 to 7.42, maintained stable physical characteristics (color, odor, consistency, homogeneity) without phase separation over a 6-month period at room temperature (22 ± 2 °C). The extract imparts a characteristic, sweet, hay-like scent with vanilla undertones and may induce a brownish color change in the formulation base.
Safety
Safety Profile
While direct CIR, SCCS, or FDA cosmetic status is not available, Melilotus Officinalis Extract is recognized for its healing properties in the European Medicines Agency (EMA) catalogue, British Herbal Compendium, and Hagers Handbuch der Pharmazeutischen Praxis. Topical application of a 2% concentration was shown to be safe in rat models, with no adverse skin reactions. SkinSAFE classifies Sweet Clover Extract as '100 Free' and 'Irritant Free', suggesting a low potential for allergic reactions or irritation in topical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Melilotus Officinalis Leaf Extract is a valuable botanical ingredient, offering comprehensive benefits for skin health through its significant anti-inflammatory, microcirculation-boosting, and regenerative actions, suitable for a wide range of skin types and concerns.
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References
Sources