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Moumoujus

MELILOTUS OFFICINALIS HERB EXTRACT.

Valuable CAS 84082-81-5 / PERFUMING

Melilotus Officinalis Herb Extract, derived from sweet clover, is a versatile botanical known for its significant anti-inflammatory, antioxidant, and microcirculation-boosting properties. It offers comprehensive benefits for skin health, including soothing discomfort, enhancing tissue regeneration, and promoting a more even skin tone.

Summary

Anti-inflammatory Antioxidant Soothing Microcirculation enhancer Emollient Astringent Anti-aging Tissue regeneration Collagen boosting Skin tone evening Phlebotonic Moisturizing Pore tightening

Science

Mechanism of Action

This extract functions as a potent anti-inflammatory agent by inhibiting the synthesis and release of inflammatory mediators such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). Its quercetin component demonstrates inhibitory activity on COX-1 and COX-2 enzymes comparable to diclofenac. By reducing capillary permeability and improving microcirculation, it effectively aids in the absorption of edema fluid. Rich in flavonoids and phenolic acids, it provides robust antioxidant protection while stimulating fibroblast growth and collagen production to support anti-aging and tissue regeneration. Additionally, it offers emollient, astringent, and phlebotonic effects, contributing to moisturization, pore tightening, and the alleviation of conditions like couperose, hematomas, and sprains.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

2%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5.15 – 7.15
0 7 14

Stability

Formulations containing Melilotus officinalis extract exhibited stable physical characteristics (color, odor, consistency, homogeneity, and no phase separation) over a 6-month storage period at 22 ± 2 °C within a pH range of 5.15 (cream) to 7.15 (gel). A significant decrease in pH was observed after 6 months, but stability was maintained within the first 2 months. The extract's stability and activity are influenced by its various constituents, including coumarins, flavonoids, phenolic acids, vitamin C, tannins, and allantoin.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Topical application of 2% Melilotus officinalis extract did not induce dermal irritation in rat studies, indicating safety at this concentration. The ingredient has a history of safe use in skincare for at least 30 years. However, broader preparations of melilot (not specifically topical skin applications at defined concentrations) have been associated with potential adverse events such as gastrointestinal complaints, allergic reactions, and photosensitivity in some studies.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Melilotus Officinalis Herb Extract is a valuable botanical offering well-rounded benefits from anti-inflammatory and antioxidant protection to microcirculation support and anti-aging effects, demonstrating safety and efficacy at topical concentrations of 2%.

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