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MELIA AZEDARACH LEAF/STEM EXTRACT.

Valuable / SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING - HUMECTANT

Melia Azedarach Leaf/Stem Extract is a botanical active renowned for its multifaceted skin benefits, including robust antimicrobial and antioxidant properties. It actively supports skin healing processes and helps soothe inflammatory conditions. Furthermore, it contributes to oil balance and can potentially influence skin pigmentation.

Antioxidant Soothing Antimicrobial Anti-inflammatory Wound Healing Sebum Regulation Melanogenesis Promotion

Science

This botanical extract operates through several mechanisms to benefit the skin. It exhibits potent antibacterial and antifungal properties, effectively combating microorganisms implicated in conditions like acne and other cutaneous infections. The extract also provides significant anti-inflammatory effects, helping to calm irritation associated with concerns such as acne, eczema, and dermatitis. Functioning as a powerful antioxidant, it protects the skin from oxidative stress caused by environmental aggressors, thereby aiding in the prevention of premature aging. Additionally, it contributes to oil balancing by regulating sebum production, which is particularly beneficial for oily and acne-prone skin types, and supports skin healing processes. It has also been shown to promote melanogenesis via the upregulation of TRP-1 protein expression.


Research

Medium confidence
Effective range 10 μg/mL–119.56 μg/mL%
Optimal

N/A


Transparency

Not commonly dusted

Considering its diverse and well-supported benefits, including significant antimicrobial, wound healing, antioxidant, anti-inflammatory, and oil-balancing properties, Melia Azedarach Leaf/Stem Extract is recognized as a valuable active ingredient rather than one commonly 'dusted' at ineffective concentrations.


The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While generally regarded as non-irritating, formulators should be mindful of potential aesthetic, stability, or other considerations that might influence its usefulness in specific product types.


Safety

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not yet evaluated Melia Azedarach Leaf/Stem Extract. However, cellular studies have indicated a high safety profile, with CC50 values of 351.4 μg/mL in Vero E6 cells. An MAE-PVA/PET hydrogel containing the extract was also found to be non-toxic. While generally considered non-irritating, formal irritancy and comedogenicity ratings are currently unknown.


Your Skin

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Melia Azedarach Leaf/Stem Extract is a valuable botanical ingredient, offering a broad spectrum of benefits including potent antimicrobial, anti-inflammatory, and antioxidant actions, making it suitable for addressing diverse skin concerns from acne to wound healing.


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