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MELIA AZADIRACHTA EXTRACT.

Valuable CAS 90063-92-6 / SKIN CONDITIONING

Melia Azadirachta Extract, derived from the neem plant, is a multi-functional botanical ingredient recognized for its comprehensive skin benefits. It effectively soothes irritation, addresses problematic skin concerns through its antimicrobial and anti-inflammatory properties, and supports overall skin vitality with antioxidants and moisturizing effects.

Summary

skin conditioning antioxidant anti-inflammatory antibacterial antifungal soothing moisturizing humectant oil balancing skin barrier support skin regeneration

Science

Mechanism of Action

This extract leverages a rich profile of bioactive compounds, including nimbidin, nimbin, and azadirachtin, to exert its effects. It demonstrates potent antibacterial activity against key acne-causing bacteria like Propionibacterium acnes and Staphylococcus species, alongside antifungal properties against Candida albicans. The extract actively reduces inflammation, calms irritated skin, and provides antioxidant protection against environmental aggressors. Additionally, it aids in balancing skin oil production, strengthens the skin's natural protective barrier, promotes skin regeneration, and offers humectant and moisturizing qualities to enhance skin texture.

Research

Clinical Evidence

High confidence
Effective range 0.5–5%
Optimal

1.5%

Key findings

  1. 01 A study utilizing 0.005% (50 μg/mL) Melia azedarach extract demonstrated a significant scratch recovery-promoting effect, comparable to TGF-β1, and exhibited antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis.
  2. 02 Typical use levels of Melia Azadirachta Leaf Extract, spanning 0.5% to 5%, have consistently shown minimal risk of irritation or sensitization for most skin types.
  3. 03 For optimal moisturizing, humectant, and soothing properties, a pure extract concentration of 1-2% is recommended in final skincare formulations, for example, when incorporating a 20% extract dissolved in glycerin at 5-10%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

The extract is typically prepared via aqueous or hydroalcoholic extraction methods. Commercial preparations, such as Neem Extract in Glycerin, often specify an optimal pH range of 4.0-6.5 for stability. It is well-suited for integration into water-based or emulsified cosmetic formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Melia Azadirachta Extract is generally regarded as safe for topical cosmetic application and is well-tolerated at typical use levels up to 5%. It has received approval from regulatory bodies, including the FDA and the European Commission (listed in EU COSING), for skin contact products. While independent assessments like EWG assign a low hazard rating, EWG notes a 'Restricted' status for 'Azadirachta Indica Leaf Extract' in some specific verified products due to limited evidence of reproductive toxicity from internal exposure studies, which is not relevant to topical use. Patch testing is recommended for individuals with highly sensitive skin or known plant allergies to ensure compatibility.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Melia Azadirachta Extract is a valuable botanical offering broad benefits, from combating problematic skin and soothing irritation to providing antioxidant protection and enhancing overall skin health and moisture.

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