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MELIA AZADIRACHTA BRANCH/LEAF EXTRACT.

Valuable / SKIN PROTECTING

Melia Azadirachta Branch/Leaf Extract, derived from the Neem tree, is a versatile botanical ingredient renowned for its comprehensive benefits across diverse skin types. It is particularly valued in precision skincare for its purifying, soothing, and protective properties, contributing to a balanced and resilient complexion.

Summary

skin conditioning antimicrobial anti-inflammatory antioxidant oil balancing soothing

Science

Mechanism of Action

This extract exerts its dermatological benefits through a rich composition of bioactive compounds, including nimbidin, nimbin, azadirachtin, flavonoids, and tannins. These components synergistically inhibit the proliferation of acne-causing bacteria like Propionibacterium acnes and demonstrate antifungal activity against Candida albicans. Furthermore, it modulates inflammatory pathways, suppressing pro-inflammatory mediators for anti-inflammatory relief, provides antioxidant protection by scavenging free radicals, helps regulate sebum production, and supports natural skin healing processes.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–5%
Optimal

N/A

Key findings

  1. 01 Clinical assessments indicate that Melia Azadirachta Branch/Leaf Extract is considered safe for cosmetic application at typical use levels between 0.5% and 5%, demonstrating minimal risk of irritation or sensitization for the majority of skin types.
  2. 02 In vitro studies have revealed significant antibacterial efficacy against various bacterial strains, including those responsible for acne, at concentrations ranging from 25 to 100 mg/mL, highlighting its potential for purifying formulations.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Optimal stability is observed within a pH range of 4.0 to 7.0, with specific performance potentially influenced by the chosen solvent system.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

The ingredient is generally considered safe for topical application, holding a low hazard rating from independent assessments at typical concentrations from 0.5% to 5%. It is approved for skin contact in the EU COSING database and by the FDA for use in cosmetic products. While generally well-tolerated, individuals with highly sensitive or allergy-prone skin are advised to perform patch testing, as mild localized redness or itching may occur. It is important to note that a related ingredient, 'Azadirachta Indica Leaf Extract,' has been listed as 'Restricted' by some sources (EWG Skin Deep) due to limited animal study evidence suggesting potential reproductive toxicity and mutagenicity, requiring thorough substantiation for certain product certifications. This cautionary note pertains to broader Neem extracts and not specifically to the 'Melia Azadirachta Branch/Leaf Extract' as per direct data provided.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Melia Azadirachta Branch/Leaf Extract is a valuable botanical ingredient, offering multifaceted benefits including antimicrobial, anti-inflammatory, antioxidant, and oil-balancing properties, making it highly suitable for diverse skin types and concerns within precision skincare formulations.

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