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Moumoujus

MELALEUCA LEUCADENDRON VIRIDIFLORA FLOWER/LEAF EXTRACT.

Valuable CAS 132940-73-9 / SKIN CONDITIONING

Melaleuca Leucadendron Viridiflora Flower/Leaf Extract is a botanical active distinguished by its robust antioxidant, anti-inflammatory, and antimicrobial capabilities. It proficiently conditions the skin by mitigating oxidative stress, modulating inflammatory pathways, and defending against microbial proliferation, making it a valuable component for comprehensive skin health solutions.

Summary

Skin Conditioning Antimicrobial Anti-inflammatory Antioxidant UV Protectant (Indirect)

Science

Mechanism of Action

This extract exerts its beneficial effects through a multi-modal mechanism involving key bioactive compounds. Terpenes, notably cineole, contribute antimicrobial efficacy by potentially compromising bacterial membrane integrity and exhibit anti-inflammatory action by modulating cytokine responses. Phenolic compounds, including flavonoids and tannins, provide significant antioxidant protection by reducing reactive oxygen species (ROS) and upregulating endogenous antioxidant enzymes such as Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), and Catalase (CAT). Furthermore, the extract demonstrates anti-inflammatory properties akin to non-steroidal anti-inflammatory drugs (NSAIDs) by inhibiting COX-2 enzyme activity.

Research

Clinical Evidence

Medium confidence
Effective range 4.8 µg/mL–200 µg/mL%
Optimal

N/A

Key findings

  1. 01 Inhibited *Klebsiella pneumoniae* bacteria and *Candida albicans* yeast, with anticancer activity against prostate cancer cells (DU-145) and no toxicity to healthy human fibroblasts (WI-38).
  2. 02 Demonstrated potent antioxidant activity.
  3. 03 Showed antioxidant activity.
  4. 04 Reduced COX-2 expression, prevented increase in reactive oxygen species (ROS), protected DNA damage, and increased antioxidant enzyme levels (SOD, GPx, CAT) in UVB-induced HaCaT cells.
  5. 05 Exhibited noticeable antioxidant activity and mediated inhibition of COX-2 enzyme activity, suggesting anti-inflammatory effects similar to NSAIDs.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Oxidation presents a potential concern; similar to related species (e.g., *Melaleuca alternifolia* tea tree oil), oxidized forms may act as sensitizers. Formulators are advised to implement measures to minimize oxidative degradation.

Conflicts

  • Aqueous formulations containing concentrations exceeding 1% may exhibit turbidity, a greenish-gray discoloration, and an undesirable odor.
  • Not recommended for fragrance applications.
  • Not recommended for flavor applications.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

No specific safety assessment from CIR, SCCS, or FDA is available for this extract. While recognized as a cosmetic skin conditioning agent, EWG indicates 'SOME' concern for skin allergies & irritation, as well as developmental & reproductive toxicity. The Good Scents Company reports 'None found' for GHS classification and hazard statements, with oral, dermal, and inhalation toxicity listed as 'Not determined'.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This extract offers valuable antioxidant, anti-inflammatory, and antimicrobial properties for skin health, though careful formulation is required to manage potential irritancy and stability, particularly above 1% concentration in aqueous systems.

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