Science
Mechanism of Action
This extract exerts its biological effects through a rich profile of phytochemicals, including alkaloids, flavonoids (such as kaempferol), phenols, tannins, saponins, and terpenoids. These compounds collectively contribute to its anti-inflammatory action by reducing oedema, provide antioxidant defense against oxidative stress, and offer antimicrobial benefits for overall skin health.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 An in vivo animal study (Wistar albino rats) demonstrated significant anti-inflammatory activity with oral administration of Maytenus senegalensis leaf extracts at 120 mg/kg, resulting in a 35% reduction in carrageenan-induced paw oedema.
Transparency
Dusting Analysis
There is no available data to suggest that Maytenus senegalensis leaf extract is commonly used at sub-efficacious percentages in cosmetic formulations for marketing purposes.
The Formula
Formulation
Safety
Safety Profile
While animal studies suggest tolerability and low toxicity at efficacious oral doses (120 mg/kg), and human oral root bark extract trials showed no severe adverse events, it's crucial to note that no specific safety assessments by regulatory bodies like CIR, SCCS, or FDA for topical cosmetic use of the leaf extract are available. Higher oral doses (1200 mg/kg) in rats indicated some toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising anti-inflammatory, antioxidant, and antimicrobial properties in preclinical and oral human studies, further specific data on topical efficacy, safety, and optimal concentration for cosmetic use is needed to fully assess its potential.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources