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Moumoujus

MASLINIC ACID.

Valuable CAS 4373-41-5 / ANTIOXIDANT, SKIN CONDITIONING

Maslinic acid is a natural triterpenoid compound recognized for its multifaceted benefits in skincare, including robust anti-inflammatory, antioxidant, and antimicrobial properties. It actively promotes skin regeneration and repair, suggesting its utility in formulations targeting overall skin health, protective effects, and reducing signs of aging.

Summary

antioxidant anti-inflammatory antimicrobial wound healing skin conditioning anti-aging melanin inhibition (limited evidence)

Science

Mechanism of Action

This ingredient operates via several distinct pathways. It demonstrates anti-inflammatory action by inhibiting pro-inflammatory mediators such as prostaglandin E2 (PGE2) and COX-2 expression, alongside cytokines like Nitric Oxide and TNF-alpha. As an antioxidant, it safeguards keratinocytes from oxidative damage, augments intrinsic antioxidant defenses, and neutralizes free radicals while mitigating reactive oxygen species (ROS) production. Its antimicrobial activity is effective against various bacteria including *Staphylococcus aureus*, *Bacillus subtilis*, and *Pseudomonas aeruginosa*. Furthermore, maslinic acid supports wound healing through stimulating fibroblast proliferation and migration, and enhances glycolysis in human keratinocytes. Limited evidence also suggests a potential role in inhibiting melanin synthesis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies observed increased human keratinocyte proliferation and WST-1 activity without compromising cell viability.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Maslinic acid exhibits limited solubility in aqueous solutions. For maximal aqueous dispersion, it should first be dissolved in an organic solvent (e.g., DMSO) prior to dilution.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Maslinic acid is generally regarded as a natural compound with low reported toxicity and minimal side effects. Oral administration studies in mice at high doses (1000 mg/kg single; 50 mg/kg repeated daily for 28 days) showed no morbidity, mortality, or toxicity. Its widespread use in beauty care products further suggests a favorable safety profile for topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Maslinic acid presents as a valuable ingredient due to its broad spectrum of benefits, including anti-inflammatory, antioxidant, antimicrobial, and pro-regenerative properties, making it suitable for diverse skincare applications despite limited specific human clinical trial data on optimal concentrations.

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