Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

MARRUBIUM VULGARE CALLUS EXTRACT.

Valuable CAS 84696-20-8 (generic) / SKIN CONDITIONING

Marrubium Vulgare Callus Extract is a sophisticated botanical active derived from white horehound, engineered for comprehensive skin protection and revitalization. It effectively soothes irritation, fortifies the skin barrier against environmental stressors, and refines texture for a visibly smoother, more radiant complexion.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Soothing Wound Healing Antimicrobial Barrier Support Skin Renewal Pore Refining Anti-histaminic

Science

Mechanism of Action

This extract functions as a potent skin conditioning agent, leveraging a rich profile of active biomolecules. Key compounds, including anti-inflammatory diterpenes like Marrubiin, and antioxidant phenolic acids such as chlorogenic acid and phenylethanoids, work synergistically. Flavonoids, including apigenin and luteolin derivatives, further contribute anti-inflammatory and anti-edema properties. Together, these components provide antioxidant protection by shielding skin from free radicals, calm irritation, support healthy cellular regeneration, and strengthen the skin's natural barrier against harmful environmental influences.

Research

Clinical Evidence

High confidence
Effective range 1–3%
Optimal

2.5%

Key findings

  1. 01 At concentrations between 1-3%, this extract exhibited anti-histaminic, anti-inflammatory, wound healing, antifungal, and antimicrobial benefits for skincare applications.
  2. 02 A human study demonstrated improved skin moisture and restored a healthy glow within one hour of topical application, and notably reduced the appearance of blackheads and rough-textured skin after four weeks.
  3. 03 In vitro, a 2.5% concentration delivered the strongest antioxidant effect, significantly decreasing intracellular reactive oxygen species in both fibroblasts and keratinocytes.
  4. 04 An in vitro assessment at 5 μg/mL confirmed the extract to be non-cytotoxic and capable of enhancing fibroblast growth, which is crucial for skin repair and regeneration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

The ingredient maintains stability within a pH range of 4.0 to 7.0. It can be efficiently processed into formulations using either warm (up to 60°C/140°F) or cold methods.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While specific CIR, SCCS, or FDA cosmetic safety assessments for Marrubium Vulgare Callus Extract are not readily available, the broader 'Marrubium Vulgare Extract' is listed with 'No penalty' across all categories by INCI Beauty, indicating a favorable safety profile. Furthermore, animal studies on ingested Marrubium Vulgare extract showed no physical signs of toxicity or mortality at daily doses up to 1000 mg/kg over three weeks.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Marrubium Vulgare Callus Extract is a valuable, multi-functional ingredient, offering robust protection against environmental damage, soothing relief for sensitive skin, and refining texture for a visibly healthier complexion suitable for all skin types.

Related

Similar Ingredients

Finding similar ingredients…