Science
Mechanism of Action
This extract employs a dual-action approach to fortify skin’s essential support network. It acts as an anti-elastase agent, preventing the degradation of existing elastic fibers, while simultaneously boosting the synthesis of critical elastin-associated proteins such as EMILIN-1 and FIBULIN-5. Furthermore, it stimulates the production of tropoelastin, the precursor to elastin, ensuring the correct formation of new elastic fibers. Complementing this, it promotes Type I collagen and glycosaminoglycan (GAG) production and actively inhibits glycation of both collagen and elastin, preserving their functionality. Its rich content of flavonoids, polyphenols, and saponins also provides conditioning and hydration benefits.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Clinical investigations and in vitro tests on fibroblasts and skin biopsies demonstrate this extract's efficacy. It has been shown to improve skin resilience and enhance elasticity by up to 10%, alongside a reduction in overall skin roughness. The extract significantly stimulates Type I collagen and glycosaminoglycan (GAG) production, and critically boosts the synthesis of elastin-associated structural proteins EMILIN-1 and FIBULIN-5.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extraction process involving solvents like ethanol or water suggests good solubility in aqueous or hydro-ethanolic systems; however, no specific optimal pH range for stability has been identified.
Safety
Safety Profile
While formal safety assessments by CIR, SCCS, or FDA are not yet available, Manilkara Multinervis Leaf Extract holds certification as a safe ingredient from Ecocert Greenlife and adheres to NPA standards. It is generally well-tolerated, with adverse reactions reported as relatively uncommon, and SkinSAFE classifies it as 'Irritant Free' and 'Fragrance Free'. As with any new ingredient, a preliminary patch test is advised.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Manilkara Multinervis Leaf Extract is a valuable ingredient for improving skin elasticity and resilience by stimulating collagen and elastin production, suitable for various skin types with a low risk of irritation.
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References
Sources