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Moumoujus

MANIHOT UTILISSIMA LEAF EXTRACT.

Valuable CAS 92456-72-9 / SKIN PROTECTING

Manihot Utilissima Leaf Extract, derived from the cassava plant, is a botanical powerhouse offering a spectrum of benefits for skin health. This versatile ingredient exhibits significant anti-inflammatory, antioxidant, and antibacterial properties, addressing concerns from sensitivity to blemishes. Furthermore, preclinical studies indicate its promising role in accelerating wound healing and providing natural UV protection.

Summary

Anti-inflammatory Antioxidant Antibacterial Wound Healing UV Filter (potential)

Science

Mechanism of Action

This extract precisely modulates inflammatory responses by inhibiting NF-kB and MAPk pathways, leading to a substantial reduction in nitric oxide (NO) and prostaglandin-E2 (PGE-2) production, and downregulating pro-inflammatory cytokines such as IL-6 and TNF-α. Its robust antioxidant activity stems from rich phenolic compounds, flavonoids (e.g., rutin, apigenin, quercetin), and carotenoids, which efficiently scavenge free radicals and protect against reactive oxygen species (ROS). The antibacterial effects are attributed to diverse phytochemicals including tannins and saponins. Additionally, it stimulates collagen synthesis, supporting tissue repair, and demonstrates broad UV absorptivity.

Research

Clinical Evidence

Medium confidence
Effective range 1.25%–30%%
Optimal

4%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for cosmetic formulation stability has been definitively identified. However, the extract's diverse components demonstrate solubility in various solvents including water, ethanol, ethyl acetate, and methanol, suggesting the presence of both water-soluble and oil-soluble active compounds, depending on the extraction method utilized.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not formally assessed Manihot Utilissima Leaf Extract. It is reported to be in use in cosmetic products under the FDA's Voluntary Cosmetic Registration Program (VCRP). While raw cassava leaves contain cyanogenic compounds, proper extraction methods are critical to reduce or remove these substances for safe cosmetic application. The Environmental Working Group (EWG) rates its concerns for cancer, allergies & immunotoxicity, and developmental & reproductive toxicity as 'LOW'. Notably, an aqueous extract incorporated into a cream did not cause skin irritation in a 20-subject human study.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Manihot Utilissima Leaf Extract is a valuable ingredient, offering significant anti-inflammatory, antioxidant, and antibacterial benefits, with emerging potential for wound healing and natural UV protection suitable for various skin types.

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