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Moumoujus

MANGIFERA INDICA LEAF EXTRACT.

Valuable CAS 90063-86-8 / SKIN CONDITIONING

This botanical extract is a multi-functional powerhouse, offering significant antioxidant and anti-inflammatory benefits. It is particularly adept at addressing concerns of oily and acne-prone skin by harmonizing sebum production and targeting Cutibacterium acnes.

Summary

Antioxidant Skin-Conditioning Agent Antimicrobial Anti-inflammatory Sebum Regulator Skin Brightener

Science

Mechanism of Action

Mangifera Indica Leaf Extract provides robust antioxidant protection by neutralizing pro-aging free radicals. It demonstrates targeted antimicrobial action against Cutibacterium acnes (C. acnes), a primary bacterium implicated in acne, through the inhibition of its lipase activity. The extract actively regulates sebum, reducing lipid synthesis in sebocytes by 40% and improving overall sebum quality. Furthermore, it exerts anti-inflammatory effects by inhibiting key pro-inflammatory enzymes and pathways, aids in reducing porphyrins, and contributes to a balanced skin microbiota. Its key constituent, mangiferin, is also associated with skin regeneration and a brightening effect.

Research

Clinical Evidence

Medium confidence
Effective range 1–1%
Optimal

1%

Key findings

  1. 01 A 1% concentration, applied for 28 days, demonstrated a 7% reduction in porphyrins on oily skin in cheek and nose areas. It also reduced lipid production in sebocytes by 40%, improved sebum quality, and inhibited C. acnes lipase activity by 29%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 8
0 7 14

Stability

Formulations containing this extract maintain stability up to 40°C but become unstable above 50°C. Given its polar phenolic and protein compounds, aqueous and hydro-alcoholic extractions are commonly employed.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

Toxicological studies, including a 90-day oral study in rats, established a No Observed Adverse Effect Level (NOAEL) of 2000 mg/kg bw/day for extracts containing 60% mangiferin. Topical formulations have been proven non-irritating in human volunteer tests, with side effects being uncommon. Cosmetic use levels generally range from 0.01% to 2% in pure form. A patch test is recommended to confirm individual skin compatibility.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Mangifera Indica Leaf Extract is a valuable multi-functional ingredient, particularly effective for acne-prone skin due to its sebum-regulating, antimicrobial, and antioxidant properties.

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