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MANGANESE TRIPEPTIDE-1.

Valuable CAS - / SKIN CONDITIONING

Manganese Tripeptide-1 is an advanced carrier peptide designed to mitigate signs of aging and hyperpigmentation. It precisely delivers manganese to skin tissues, activating crucial antioxidant pathways and regulating melanin production for a more even, resilient complexion.

Summary

Skin conditioning Antioxidant Hyperpigmentation reduction Collagen stimulation Anti-inflammatory

Science

Mechanism of Action

This peptide functions as a carrier, delivering manganese to cutaneous tissues where it activates manganese superoxide dismutase (Mn-SOD), a mitochondrial enzyme. This process significantly enhances Mn-SOD activity, reducing oxidative stress by neutralizing superoxide radicals and thereby safeguarding extracellular matrix integrity from UV radiation-induced collagen and elastin degradation. Furthermore, it inhibits hyperpigmentation by suppressing tyrosinase transcription via the inhibition of MITF (microphthalmia-associated transcription factor) nuclear translocation and by upregulating Nrf2, which boosts the synthesis of glutathione, an endogenous depigmenting agent. Manganese Tripeptide-1 also stimulates collagen production and intervenes with collagen degradation, leading to improved skin elasticity and firmness.

Research

Clinical Evidence

High confidence
Effective range 1–5%
Optimal

2%

Transparency

Dusting Analysis

Not commonly dusted

The provided research does not contain specific data to assess if Manganese Tripeptide-1 is commonly 'dusted' in cosmetic formulations. Clinical efficacy has been observed within the 1-5% concentration range.

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 7
0 7 14

Stability

Manganese Tripeptide-1 is stable within a physiological pH range of 5.5 to 7.0. Its moderate water solubility (0.5 mg/mL at 25°C) may necessitate formulation with penetration enhancers, such as ethosomes or liposomes, to optimize delivery across the stratum corneum.

Conflicts

  • Alpha hydroxy acids (AHAs) may reduce the efficacy of peptides.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Tripeptide-1 and its metal salts, including Manganese Tripeptide-1, are safe for use in cosmetic products at concentrations up to 5%. Clinical studies reported the ingredient to be well tolerated, with no observed erythema, desquamation, or significant cutaneous inflammation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Manganese Tripeptide-1 is a valuable multi-functional ingredient, clinically proven to reduce hyperpigmentation, enhance skin elasticity, and provide robust antioxidant protection, making it highly suitable for targeted anti-aging and skin brightening formulations.

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