Science
Mechanism of Action
This extract has been observed to possess antioxidant and antimicrobial properties in broader botanical studies. Historically, it was believed to stimulate localized blood flow and metabolism, potentially aiding tissue regeneration and healing, aligning with its role as a skin conditioning and tonic agent.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data indicates common 'dusting' practices for this ingredient. Given its extreme toxicity, even at low concentrations, any intentional inclusion in a formulation would require stringent safety assessments and precise, minimal percentages.
The Formula
Formulation
Conflicts
- Anticholinergic drugs
- Other oral medications (due to potential for altered absorption)
Safety
Safety Profile
Mandragora officinarum is an exceptionally poisonous plant. Its root contains highly active tropane alkaloids, including hyoscyamine, scopolamine, and atropine, present at approximately 0.4%. Ingestion can lead to severe systemic anticholinergic, psychoactive, and hypnotic effects, including vision impairment, rapid heart rate, and hallucinations, potentially resulting in death. Topical use presents a high risk of allergic and irritating contact dermatitis. The FDA has not recognized this ingredient as safe or effective for certain over-the-counter uses, underscoring its significant safety concerns.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its extreme toxicity, high irritancy risk, lack of established safety for cosmetic use, and the presence of potent alkaloids, this ingredient is strongly advised against for skincare formulations.
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