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MALLOTUS PHILIPPENSIS BARK EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Mallotus Philippensis Bark Extract is a potent botanical extract recognized for its significant multi-functional benefits in precision skincare. It offers robust antioxidant and anti-inflammatory actions, while also actively promoting the skin's natural regenerative processes to enhance healing and tissue remodeling.

Summary

Antioxidant Skin-conditioning Humectant

Science

Mechanism of Action

This extract operates through a dual mechanism to support skin health. Firstly, it exerts powerful anti-inflammatory effects by inhibiting key mediators such as interleukin-1ß, inducible nitric oxide synthases, and nuclear factor-kappa B. Secondly, it acts as a potent antioxidant, exhibiting marked radical scavenging ability. Beyond these, the extract uniquely facilitates wound healing by serving as a chemoattractant for mesenchymal stem cells (MSCs), thereby stimulating their proliferation, migration, and directed homing to sites of damage, which ultimately leads to improved tissue repair and remodeling.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Concentrations as low as 0.16-4 µg/mL (in vitro) have been shown to enhance mesenchymal stem cell proliferation and migration, supporting wound healing.
  2. 02 Topical application in mouse models significantly improved house dust mite-induced atopic dermatitis-like inflammation by inhibiting inflammatory mediators (interleukin-1ß, inducible nitric oxide synthases, nuclear factor-kappa B).
  3. 03 Exhibited strong antioxidant activity, with an IC50 of approximately 35.84 µg/mL for methanol extract (DPPH assay) and a radical scavenging rate of up to 97% for fruit extract.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Extracts are typically obtained using solvents like water, alcohol, or carbon dioxide. The water solubility of the extract can be significantly improved by adding a base component, particularly for compounds such as rottlerin.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific CIR, SCCS, or FDA status for cosmetic use has been found. General safety data regarding acute and subacute toxicity, cardio- and immunotoxicity for crude extracts or isolated compounds is limited. The Good Scents Company indicates 'Not determined' for oral, dermal, and inhalation toxicity, with no GHS classification or hazard statements identified.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Mallotus Philippensis Bark Extract is a valuable ingredient, offering multi-faceted benefits in anti-inflammation, antioxidant defense, and wound healing, making it highly beneficial for various skin concerns.

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