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MAGNOLIA GRANDIFLORA LEAF EXTRACT.

Valuable CAS 85085-47-8 / SKIN CONDITIONING

Magnolia Grandiflora Leaf Extract is a sophisticated botanical ingredient rich in active compounds like honokiol and magnolol. It delivers multifaceted benefits, acting as a potent antioxidant and anti-inflammatory agent, while also supporting skin's structural integrity and promoting a clearer, more luminous complexion.

Antioxidant Soothing Moisturizer Anti-inflammatory Anti-aging Antimicrobial Skin Brightening Sebum-regulating

Science

At a molecular level, Magnolia Grandiflora Leaf Extract provides comprehensive skin benefits. Its powerful antioxidant capacity, driven by key components such as honokiol and magnolol, effectively neutralizes free radicals, safeguarding the skin from environmental oxidative stress and mitigating premature aging. The extract exhibits robust anti-inflammatory properties by inhibiting NF-κB activation and reducing the release of inflammatory messengers like TNF-α and IL-8, thereby calming redness, alleviating sensitivity, and combating 'inflamm-aging' effects that contribute to wrinkle formation. For anti-aging, it helps maintain skin firmness and elasticity by inhibiting enzymes responsible for collagen and elastin degradation. Its antimicrobial actions are effective against bacteria such as *Staphylococcus aureus* and *Propionibacterium acnes*, offering benefits for blemish-prone skin. Furthermore, it contributes to skin brightening by inhibiting melanin production and downregulating the expression of tyrosinase and tyrosinase-related protein 1 (TRP-1), which aids in diminishing dark spots and hyperpigmentation. Lastly, it assists in regulating sebum production, proving advantageous for oily and combination skin types.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A study on *Magnolia grandiflora leaf volatile oil* at 0.5% (V/V) demonstrated significant bacteriostatic activity against various bacteria, including *Staphylococcus aureus* and *Escherichia coli*.
  2. 02 Research on *Magnolia grandiflora flower extract* indicated a dose-dependent inhibition of mushroom tyrosinase activity (IC50 11.1% v/v).
  3. 03 The same *flower extract* effectively suppressed intracellular tyrosinase activity in B16F10 cells at an IC50 of 13.6% (v/v).
  4. 04 *Magnolia grandiflora flower extract* decreased melanin content in B16F10 cells in a dose-dependent manner, with an IC50 of 25.6% (v/v).

Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Extraction can be performed using gentle processes, such as ethanol-water mixtures or CO2 extraction, to preserve its active compounds. It's noted that some beneficial components, like magnolol, may exhibit limited water solubility.

Synergies

  • Other antioxidants for enhanced protection against oxidative stress.
  • Calming ingredients to further soothe sensitive or reddened skin.
  • Brightening agents to amplify effects on hyperpigmentation.

Safety

CIR Status
Not reviewed
Sensitization risk Low

Magnolia grandiflora extracts are consistently reported as non-cytotoxic, suggesting excellent suitability for cosmetic applications. This ingredient is generally well-tolerated and considered gentle on the skin, including for individuals with sensitive skin.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Magnolia Grandiflora Leaf Extract is a valuable ingredient, offering broad-spectrum benefits from potent antioxidant and anti-inflammatory properties to anti-aging and skin brightening effects, making it suitable for a diverse range of skin concerns and types.


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