Science
Mechanism of Action
This extract functions by delivering a spectrum of phytochemicals, including terpenoids, tannins, and phenolic compounds, which collectively contribute to its biological activity. Its primary mechanisms involve neutralizing harmful free radicals, thereby providing antioxidant protection, and inhibiting the growth of specific bacteria like Staphylococcus aureus.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In an in vitro study, the methanol extract exhibited high free radical scavenging activity, demonstrating an IC50 of 3.37 µg/ml.
- 02 The extract also displayed dose-dependent antibacterial activity specifically against Staphylococcus aureus in laboratory settings.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extraction and defatting processes suggest the presence of both polar and non-polar compounds, indicating potential stability across various formulation types.
Safety
Safety Profile
Machilus Odoratissima Bark Extract has not undergone specific safety reviews by CIR, SCCS, or FDA, and is listed as 'Not rated' by Paula's Choice. While a related species, Machilus Thunbergii Bark Extract, generally has a good safety profile, some individuals, particularly those with sensitive skin, may experience allergic reactions such as rashes or redness, leading regulatory authorities to recommend a patch test for related extracts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Machilus Odoratissima Bark Extract presents valuable antioxidant and antibacterial properties observed in vitro; however, comprehensive human clinical safety data and precise formulation guidelines are currently limited for this specific species.
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References
Sources