Science
Mechanism of Action
Maackia Amurensis Branch Extract operates through distinct mechanisms to enhance skin luminosity and firmness. For skin brightening, it inhibits α-MSH-induced melanin synthesis and actively suppresses the expression of critical melanogenesis regulators: microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related proteins (TRP)-1 and TRP-2. Concurrently, its anti-wrinkle action involves decreasing ultraviolet A-induced matrix metalloproteinase (MMP)-1 expression, which is responsible for collagen degradation, and significantly increasing soluble collagen synthesis. Key compounds contributing to these effects include formononetin, genistein, trans-resveratrol, piceatannol, and tectoridin.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
No specific data regarding dusting potential is available in the provided research.
The Formula
Formulation
Stability
No specific stability notes provided.
Safety
Safety Profile
Official safety assessments by regulatory bodies such as CIR, SCCS, or FDA are not yet available. In vitro studies on B16F1 melanoma cells indicated no cytotoxicity up to 75 μg/mL. However, in CCD-986sk human fibroblast-like cells, no cytotoxicity was observed at 37.5 µg/mL, but cytotoxicity began to appear at concentrations exceeding 50 µg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Maackia Amurensis Branch Extract is a valuable ingredient, demonstrating significant in vitro efficacy in both reducing melanin synthesis and boosting collagen production for comprehensive skin rejuvenation.
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References
Sources