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LYSINE CARBOXYMETHYL CYSTEINATE.

Valuable CAS 79458-68-7, 49673-81-6 / HAIR WAVING OR STRAIGHTENING, SKIN CONDITIONING

Lysine Carboxymethyl Cysteinate (LCC) is a cutting-edge amino acid derivative that functions as a potent glutathione precursor, significantly enhancing the skin's natural antioxidant defenses. It precisely targets and mitigates oxidative stress while actively promoting cellular renewal, hydration, and overall skin resilience.

Summary

Antioxidant Skin-conditioning Hair conditioning Anti-aging Hydrating Exfoliating (mild) Barrier Support Anti-inflammatory Cell Renewal Stabilizer

Science

Mechanism of Action

LCC operates primarily by boosting endogenous glutathione (GSH) levels within primary human keratinocytes and skin tissue samples, thereby fortifying the skin's inherent antioxidant capacity. This action provides robust protection against oxidative damage from environmental aggressors such as blue light and UVB radiation, preventing barrier disruption and hyperpigmentation. Beyond its antioxidant prowess, LCC actively reduces the production of inflammatory mediators, stimulates cell renewal, and improves hydration. It exerts a tightening effect, visibly reducing the appearance of fine lines and preventing new wrinkle formation. Furthermore, LCC contributes to enhanced skin softness and elasticity, offers a mild keratoplastic action for gentle exfoliation without irritation, and stabilizes other vital antioxidants like vitamins C and E, reinforcing their efficacy.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

2%

Key findings

  1. 01 Reduced reactive oxygen species (ROS) generation by 3% in blue-light-exposed human keratinocytes.
  2. 02 Decreased reactive oxygen species (ROS) levels by 38% in blue-light-exposed human keratinocytes.
  3. 03 Decreased reactive oxygen species (ROS) levels by 48% in blue-light-exposed human keratinocytes.
  4. 04 Topical application on skin explants for 24 hours significantly elevated glutathione (GSH) signals in epidermal regions.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The inclusion of lysine in the compound is crucial for enhancing its solubility and safeguarding the essential thiol functional group (S–H) from potential degradation.

Synergies

  • Vitamins C
  • Vitamins E

Safety

Safety Profile

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of α-amino acids, including lysine derivatives, for cosmetic applications up to 5% concentration. Lysine Carboxymethyl Cysteinate is considered non-irritant for skin and eyes and is hypoallergenic. The FDA also recognizes L-amino acids as generally safe food additives. EWG Skin Deep rates concerns for Cancer, Allergies & Immunotoxicity, and Developmental and Reproductive Toxicity as 'Low'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Lysine Carboxymethyl Cysteinate is a valuable ingredient, leveraging its role as a glutathione precursor to provide significant antioxidant protection, anti-aging benefits, and comprehensive skin conditioning.

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