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Ingredient directory

Lysimachia Clethroides Extract

Lysimachia Clethroides Extract, derived from the Gooseneck Loosestrife plant, is a botanical powerhouse exhibiting potent anti-inflammatory and antioxidant properties. Research indicates its capacity to calm cellular inflammation and neutralize oxidative stress, positioning it as a promising ingredient for targeted skin revitalization and protection.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Anti-inflammatory Antioxidant

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by attenuating lipopolysaccharide (LPS)-stimulated responses in macrophages, specifically inhibiting nitric oxide (NO) release and reducing the production of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6. It also regulates key inflammatory mechanisms, including the phosphorylation of IRF3 and STAT1. Furthermore, Lysimachia Clethroides Extract demonstrates significant antioxidant activity, attributed to its rich composition of triterpenoids, flavonoids, organic acids, and sterols, which collectively combat oxidative stress.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In dose-dependent studies on Raw 264.7 cells, the extract significantly inhibited LPS-stimulated nitric oxide (NO) release and the production of pro-inflammatory cytokines IL-1β and IL-6, underscoring its anti-inflammatory capabilities.
  2. 02 Demonstrated robust antioxidant activity across multiple assays, including DPPH, ABTS, and FRAP, indicating its ability to neutralize free radicals.
  3. 03 Induced endothelium-dependent vasodilation in rat aorta rings, with an effective dose 50 (ED50) measured at 6.1 μg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract's components are noted to be readily soluble in polar solvents such as water, methanol, and ethanol. Its natural prevalence in damp environments further supports the presence of water-soluble active constituents, suggesting good aqueous compatibility for formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety assessments by established cosmetic regulatory bodies like CIR (Cosmetic Ingredient Review) or SCCS (Scientific Committee on Consumer Safety) are not available. Its status with the FDA for cosmetic use also remains unknown, indicating a lack of comprehensive dermatological safety data.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Lysimachia Clethroides Extract presents as a valuable botanical due to its robust in-vitro and animal model evidence for anti-inflammatory and antioxidant properties, though further dermatological safety and human topical efficacy studies are essential to fully ascertain its potential in precision skincare.

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