Science
Mechanism of Action
This ingredient operates by significantly suppressing inflammatory responses, specifically reducing the production of nitric oxide (NO) and tumor necrosis factor (TNF)-α, and downregulating inducible NO synthase. It further represses interleukin (IL)-6 generation. Its anti-androgenic effects are mediated by the inhibition of testosterone 5α-reductase, primarily due to lipophilic constituents like oleic, linoleic, and palmitic acids. Additionally, it aids in cellular turnover, gently removing dead skin cells to unclog pores and improve skin hydration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Ethanol extracts of Lygodium japonicum spores (ELJ) demonstrated significant suppression of nitric oxide (NO) and tumor necrosis factor (TNF)-α production in LPS-stimulated murine RAW 264.7 macrophages at concentrations ranging from 50 to 300 µg/ml. Repression of interleukin (IL)-6 was observed at concentrations ≥200 µg/ml.
- 02 An aqueous ethanol extract of Lygodii Spora exhibited in vitro testosterone 5α-reductase inhibitory activity and in vivo anti-androgenic effects, including reducing flank organ growth in castrated Syrian hamsters and promoting hair regrowth in testosterone-treated C57Black/6CrSlc mice. The active principles identified were oleic, linoleic, and palmitic acids.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Lygodium japonicum spores demonstrate robust stability, maintaining viability for up to five years under controlled conditions and showing resistance to freezing temperatures. The plant from which they are derived thrives in circumneutral soil pH, typically between 6.5 and 7.5.
Safety
Safety Profile
No specific GHS classification or determined oral/dermal/inhalation toxicity has been found. A general safety recommendation advises against use during pregnancy, and individuals who are nursing or taking medications should consult a physician.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Lygodium japonicum Spore is a valuable multi-functional ingredient, offering scientifically supported anti-inflammatory and anti-androgenic benefits, complemented by its exfoliating and moisturizing properties, making it suitable for a broad spectrum of skin types.
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References
Sources