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Moumoujus

LYCOPUS MAACKIANUS CALLUS CULTURE EXTRACT.

Insufficient Data CAS - / ANTIOXIDANT

Lycopus Maackianus Callus Culture Extract is a botanical ingredient derived from the cultured cells of the Lycopus maackianus plant. It is primarily recognized for its potent antioxidant and anti-inflammatory properties, offering potential in mitigating oxidative stress and modulating inflammatory responses in biological systems.

Summary

Antioxidant Anti-inflammatory

Science

Mechanism of Action

This extract functions by augmenting cellular antioxidant defenses, demonstrated by increased DPPH and ABTS radical scavenging activity. Its anti-inflammatory efficacy is mediated through the inactivation of the nuclear factor-kappa B (NF-κB) pathway, leading to a reduction in nitric oxide, prostaglandin E2, interleukin-6, and tumor necrosis factor-α production. Additionally, it confers protection against oxidative stress-induced cellular damage and promotes the expression of heme oxygenase-1 and the translocation of nuclear factor E2-related factor 2 (Nrf2).

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A methanol extract of Lycopus maackianus (not specifically callus culture extract) demonstrated inhibitory effects on nitrite production at a non-toxic concentration of 0.01% (100 µg/mL). Toxicity was observed at 0.02%.
  2. 02 A methanol extract of Lycopus maackianus (not specifically callus culture extract) exhibited antioxidant effects at concentrations ranging from 0.0003125% to 0.0025% (3.125 µg/mL to 25 µg/mL). A significant reduction in survival rate was observed at 0.005%.

Transparency

Dusting Analysis

Not commonly dusted

There is no available information to indicate that Lycopus Maackianus Callus Culture Extract is commonly used at concentrations considered excessive or that specific thresholds lead to reduced efficacy or increased risk.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Specific data regarding the optimal pH range for stability or solubility (water/oil) in cosmetic formulations for Lycopus Maackianus Callus Culture Extract is not available. Studies on Lycopus maackianus have utilized methanol extracts, suggesting solubility in methanol. General plant extracts can typically be solvent-extracted using various mediums including water, alcohol, or carbon dioxide.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by major regulatory bodies such as the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or the FDA have been found for Lycopus Maackianus Callus Culture Extract. Insufficient publicly available research on its safety has resulted in an 'not rated' status from some cosmetic ingredient databases.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Lycopus Maackianus Callus Culture Extract demonstrates promising antioxidant and anti-inflammatory mechanisms in preliminary non-human studies with a related extract, but comprehensive efficacy and safety data for this specific ingredient in human skincare remains insufficient.

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